Tissue: The anatomical tissue this cell line originates from, standardized using Cell Model Passports (Sanger).
Cancer: The cancer type classified using OncoTree (MSK) and mapped to the NCI Thesaurus (NCIt) ontology.
MSI: Microsatellite Instability status. MSS = Microsatellite Stable (no instability detected). MSI = Microsatellite Instable (defective DNA mismatch repair, often linked to higher mutational burden and immunotherapy response).
Origin: Where the sample was collected from. Metastasis = derived from a metastatic site (e.g. pleural effusion). Primary = derived directly from the primary tumour.
Sources: Cell Model Passports, OncoTree, COSMICTissue: Anatomical tissue of origin, standardized via Cell Model Passports (Sanger).
Cancer Type / Subtype: Disease classification from OncoTree (MSK), mapped to the NCI Thesaurus ontology.
NCIt Code: NCI Thesaurus disease identifier, the unified ontology used across COSMIC, DepMap, and Cellosaurus.
Tissue Status: Whether the sample is a primary tumour, metastasis, or other origin.
Growth: In-vitro growth pattern (e.g., Adherent, Suspension).
Sources: Cell Model Passports · DepMap · COSMICSex: Biological sex of the patient the cell line was derived from.
Age: Age at time of sample collection (Adult, Paediatric, etc.).
Ethnicity: Self-reported ethnicity from the source database.
Primary Site / Subtype: COSMIC-reported anatomical site and sub-classification of the original tumour.
Sources: COSMIC · Cell Model PassportsMSI Status: Microsatellite instability status (MSS = stable, MSI = instable). From Cell Model Passports.
Ploidy: Average genome ploidy estimated from copy number data.
Mutational Burden: Mutations per megabase of coding sequence.
Data Sources: Which databases contributed mutation data for this cell line. Highlighted = present, faded = not available.
Sources: DepMap / CCLE · COSMIC CLPTop 20 Mutated Genes
Bar chart showing the 20 genes with the highest mutation count in this cell line across all data sources.
Use the slider bar below the chart to pan and zoom across genes. You can also scroll inside the chart area.
Mutation counts include all coding variants (substitutions, insertions, deletions) from COSMIC and DepMap.
Sources: CAN-IMMUNE aggregatedHLA Information
HLA Class I (A, B, C): Present peptides to CD8+ cytotoxic T cells. Critical for neoantigen-based immunotherapy target prediction.
HLA Class II (DQA1, DPB1, DQB1, DRB1): Present peptides to CD4+ helper T cells.
Each locus shows two alleles (one per chromosome). Alleles are in standard WHO nomenclature (e.g., 02:17).
HLA typing is used by CAN-IMMUNE to match mutant peptides against the cell line's specific HLA profile.
Source: Cellosaurus / PubMedMutations
Complete list of coding mutations (amino acid changes) identified in this cell line.
CAN-IMMUNE ID: Unique identifier linking each mutation to its 25-mer mutant peptide.
Mutation AA / CDS: Amino acid and coding DNA sequence change notation.
Mutant Peptide: 25-mer peptide centred on the mutation site, used for epitope prediction and HLA binding analysis.
Use search and column sorting to explore. Data is loaded on demand from the server.
Sources: COSMIC CLP · DepMap / CCLE| Gene | Mutation AA | Mutation CDS | Type | Source | Transcript | CAN-IMMUNE ID | Mutant Peptide | Ref |
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