Database Statistics

CAN-IMMUNE v0.3 · released 2026-08-11 · COSMIC v104 + DepMap 2026Q2

14,727,110
Documented mutations
4,531,600
Unique mutant peptides
20,081
Genes
2,052
Cell lines
31
Tissues of origin
163
Histology types
55
Cancer types
415,762
Cross-source shared peptides
Cell line vs tissue coverage across tissues

Samples, genes & mutation load per tissue

Bubble size = #samples / #genes (scaled within each row so both are legible); colour = total documented mutations. OncoTree lineages.
Curated cancer-type taxonomy

Tissue of origin → Cancer type

The 55 curated cancer types grouped under their 31 tissues of origin (52,431 annotated samples, tissue + cell line). Inner ring = tissue, outer ring = cancer type; sized by sample count, each cancer type inheriting its tissue's colour. Click a wedge to zoom, click the centre to reset.
Samples by tissue, stacked by cancer type

Cell lines

Each bar is a tissue; segments are its curated cancer types (OncoTree), sized by sample count. Hover a segment for the exact number.

Tissue samples

COSMIC + PubMed primary tumours, same two-level taxonomy.
Data sources & mutation composition

Mutations & peptides by source

COSMIC (tissue & cell line), DepMap/CCLE, PubMed

Mutation type

Neoepitope-producing substitutions only

Single-nucleotide variants

Substitution spectrum (CDS)
Recurrent mutation hotspots

Most recurrent variant per gene

Ranked by number of samples carrying the variant (one canonical variant per gene). Click a gene for details.
GeneVariantSamplesMutationsRecurrence
BRAF p.V600E 2,023 3,909
KRAS p.G12D 1,361 5,228
TP53 p.R175H 864 4,974
PIK3CA p.E545K 842 1,650
HLA-A p.L180Q 716 720
IDH1 p.R132H 667 1,997
NRAS p.Q61K 427 427
HLA-C p.S140Y 268 536
AKT1 p.E17K 224 1,319
BCLAF1 p.N627S 221 663
MUC19 p.N6549D 212 212
ZNF814 p.A337V 211 211
HLA-B p.E69K 205 205
SF3B1 p.K700E 203 203
JAK2 p.V617F 196 196
HLA-DRB5 p.I248L 176 176
FNDC10 p.H225P 173 173
SLC25A5 p.T221R 171 171
MUC3A p.V43A 168 182
FBXW7 p.R465C 160 464
MT-CYB p.F18L 156 156
CENPB p.T150P 154 154
GNAS p.R201C 153 153
CTNNB1 p.T41A 153 4,095
NTN3 p.T345P 152 152
GOLGA8M p.S553F 145 145
AHNAK2 p.N2143D 143 143
H3F3A p.K28M 121 484
GNAQ p.T96S 119 119
LILRA2 p.W175S 119 119
MUC21 p.T323V 118 118
TTC6 p.E252D 116 116
XIRP2 p.P252S 116 122
CHEK2 p.K373E 116 239
TRIM48 p.Y192H 115 115
IGLV5-45 p.I99L 111 111
XPO1 p.E571K 111 315
CHGB p.R278H 106 106
PLEKHG3 p.R426W 106 106
HLA-DRB1 p.S66N 105 105
SMAD4 p.R361H 105 202
U2AF1 p.S34F 104 208
PSMB11 p.C145R 104 104
SNCAIP p.P335L 103 103
KRBA1 p.S369R 103 206
PKD1L2 p.T1446K 103 103
HLA-DQB1 p.P84E 102 102
PSG3 p.K241N 102 306
ZNF423 p.I1158T 102 204
PCDHAC1 p.A230V 102 204
CUX2 p.P951S 102 102
SALL3 p.A185L 101 102
RNF17 p.P361S 101 103
ERBB2 p.S280F 100 300
DDB1 p.N696S 100 100
PGM5 p.I98V 100 200
CYFIP2 p.S573T 100 200
LILRB3 p.T201M 98 98
RAC1 p.P29S 98 191
DPYSL4 p.A116S 98 98
CSF1R p.Q426K 98 98
TMPRSS13 p.A77G 95 475
TPSG1 p.R267H 95 95
NSD2 p.E1099K 95 344
MUC4 p.R3900H 94 188
KRTAP9-6 p.G106C 94 94
ARHGAP33 p.P962L 93 93
FBF1 p.A919G 93 93
CHAT p.D273H 93 279
TGOLN2 p.G287E 93 372
ZNF608 p.H1463Y 93 93
SLC30A2 p.P14R 92 184
ZXDA p.Q138L 92 92
PTEN p.R130Q 92 92
FGFR3 p.S249C 91 355
MUC5B p.S4698L 91 91
RNF214 p.S134C 91 182
SCRIB p.A906V 90 180
TRPM6 p.L1244I 90 180
FAT3 p.A4286P 90 90
EPPK1 p.R2214H 90 90
NKAIN3 p.D141N 89 89
TENT5B p.H416R 89 89
MICAL3 p.I651M 88 440
ROR2 p.R596Q 88 88
GLOD4 p.A281D 88 88
TRMT2A p.L214I 88 91
DGCR8 p.G217V 87 174
CELSR2 p.R2015K 86 86
MRM3 p.V339N 86 86
MGAM p.V1569I 85 170
N4BP3 p.R338W 84 84
USP6 p.R133K 84 168
IDH2 p.R140Q 84 84
KRTAP4-3 p.Q31L 84 84
TRAP1 p.S77N 84 84
ANKRD35 p.A722S 83 83
HRAS p.Q61R 83 407
KRTAP4-5 p.C79S 82 82
GUF1 p.G10W 82 82

Amino-acid substitutions

Top 25 protein-level changes across all sources

Top genes by documented mutations

Ranked by total documented mutations across all sources
GeneMutationsPeptidesSamplesShare
TP53 196,883 978 12,361
TTN 144,143 20,061 11,492
CTNNB1 65,774 431 1,681
PCDH15 39,044 3,186 2,652
CACNA1C 33,634 1,441 1,567
MUC4 30,497 3,600 4,286
CACNA1G 29,983 1,066 1,195
KCNMA1 27,242 872 893
PLEC 23,118 2,173 2,215
SMARCA4 22,157 1,013 1,402
CSMD1 21,746 3,003 3,337
CACNA1A 20,675 1,239 1,465
OBSCN 18,789 4,616 3,862
MAPK10 18,602 328 284
ADGRL3 18,380 1,178 1,423
Highest-mutation tissues, histologies & cell lines

Tissues

Documented mutations per OncoTree lineage
TissueMutationsSamples
Skin 2,227,568 2,097
Esophagus/stomach 1,727,390 6,112
Bowel 1,698,268 3,292
Lung 1,279,865 3,128
Uterus 829,897 724
Liver 513,775 2,164
Cns/brain 469,701 2,906
Lymphoid 436,879 6,033
Breast 423,178 3,292
Bladder/urinary Tract 415,746 951
Thyroid 343,671 1,599
Head And Neck 340,128 1,638

Histology types

Documented mutations per histology
HistologyMutationsSamples
Carcinoma 9,732,686 29,936
Malignant Melanoma 1,857,765 1,960
Lymphoid Neoplasm 632,359 6,166
Other 463,643 1,732
Glioma 450,764 2,148
Haematopoietic Neoplasm 144,606 2,549
Adenoma 138,773 359
Gastrointestinal Stromal Tumour 124,401 133
Colorectal Adenocarcinoma 100,012 88
Neuroblastoma 73,432 1,411
Non-Small Cell Lung Cancer 66,479 147
Endometrial Carcinoma 57,160 34

Cell lines

Highest documented mutation burden
Cell lineMutationsGenes
SNU-1040 50,997 9,553
SNU-81 20,966 4,904
HCT-15 20,907 5,605
HCC2998 20,730 4,824
CW-2 19,347 4,850
KARPAS-45 18,696 4,799
HT-115 16,316 4,213
SNU-175 15,890 4,306
MeWo 14,212 3,605
Jurkat 14,079 4,049
MOLT-4 14,008 3,585
EN 13,879 3,862
Release history
VersionReleasedMutationsUnique peptides
v0.3 2026-08-11 14,673,401 4,485,395

"New peptides" on the dashboard is computed as the difference in unique mutant peptides between the two most recent releases.