Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 5,194 | 1,146 | 3,955 |
| Samples | 3,188 | 812 | 2,325 |
| Peptides | 2,692 | 538 | 2,235 |
Function
AHNAK2 · AHNAK nucleoprotein 2
This gene encodes a large nucleoprotein. The encoded protein has a tripartite domain structure with a relatively short N-terminus and a long C-terminus, separated by a large body of repeats. The N-terminal PSD-95/Discs-large/ZO-1 (PDZ)-like domain is thought to function in the formation of stable homodimers. The encoded protein may play a role in calcium signaling by associating with calcium channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 2500 amino-acid changes on canonical ENST00000333244 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in AHNAK2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in AHNAK2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 21/40 52% | 0/0 0% |
| Oral Cavity Carcinoma | 17/54 31% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 7/26 27% | 0/0 0% |
| Glioblastoma | 24/98 24% | 0/0 0% |
| Acute Myeloid Leukemia | 19/90 21% | 0/0 0% |
| Endometrial Carcinoma | 22/42 52% | 91/612 15% |
| Chronic Myelogenous Leukemia | 4/25 16% | 0/0 0% |
| Melanoma | 57/210 27% | 253/1899 13% |
| Non-Small Cell Lung Carcinoma | 85/304 28% | 151/1390 11% |
| Colorectal Carcinoma | 50/143 35% | 333/3239 10% |
| Hodgkins Lymphoma | 1/16 6% | 13/122 11% |
| Chordoma | 2/7 29% | 0/13 0% |
| Bladder Carcinoma | 13/58 22% | 88/956 9% |
| Squamous Cell Lung Carcinoma | 12/57 21% | 72/810 9% |
| Gastric Carcinoma | 26/74 35% | 140/1809 8% |
| Other Solid Cancers | 24/94 26% | 117/1515 8% |
| Cervical Carcinoma | 9/35 26% | 29/422 7% |
| Unknown | 2/10 20% | 1/29 3% |
| Neuroendocrine Tumour | 41/154 27% | 13/577 2% |
| Osteosarcoma | 10/45 22% | 5/166 3% |
| Hepatocellular Carcinoma | 11/46 24% | 143/2210 6% |
| Ewings Sarcoma | 15/63 24% | 7/262 3% |
| Ovarian Carcinoma | 29/109 27% | 45/998 5% |
| Esophageal Carcinoma | 4/23 17% | 45/769 6% |
| Plasma Cell Myeloma | 13/44 30% | 8/305 3% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 8/133 6% |
| Rhabdomyosarcoma | 6/33 18% | 6/171 4% |
| Burkitts Lymphoma | 10/32 31% | 3/196 2% |
| Biliary Tract Carcinoma | 11/54 20% | 46/950 5% |
| Germ Cell Tumour | 7/25 28% | 4/169 2% |
Mutation Distribution
Where AHNAK2 is mutated · all tissues, split by cell line vs tissue
How many mutations in AHNAK2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 5,194 mutations in AHNAK2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|