Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 196,883 | 10,820 | 182,210 |
| Samples | 12,361 | 1,376 | 10,753 |
| Peptides | 978 | 368 | 923 |
Function
TP53 · Tumor protein p53
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016].
Isoforms & Proteins
20 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000269305 | P04637 | 13,850 | 768 |
| ENST00000610292 | P04637-4 | 12,772 | 741 |
| ENST00000445888 | P04637 | 12,357 | 733 |
| ENST00000619485 | P04637-4 | 12,305 | 708 |
| ENST00000620739 | P04637-4 | 12,305 | 708 |
| ENST00000455263 | P04637-3 | 12,130 | 689 |
| ENST00000420246 | P04637-2 | 12,098 | 681 |
| ENST00000359597 | J3KP33* | 12,095 | 680 |
| ENST00000610538 | P04637-6 | 12,065 | 662 |
| ENST00000622645 | P04637-5 | 12,047 | 657 |
| ENST00000504937 | P04637-7 | 11,409 | 592 |
| ENST00000504290 | P04637-9 | 11,168 | 546 |
| ENST00000510385 | P04637-8 | 11,151 | 541 |
| ENST00000619186 | A0A087X1Q1* | 10,239 | 502 |
| ENST00000610623 | A0A087WT22* | 9,998 | 456 |
| ENST00000618944 | A0A087WXZ1* | 9,981 | 451 |
| ENST00000413465 | E7EQX7* | 8,907 | 550 |
| ENST00000514944 | E9PFT5* | 3 | 3 |
| ENST00000635293 | A0A0U1RQC9* | 2 | 2 |
| ENST00000604348 | S4R334* | 1 | 1 |
Gene Properties
Recurrent Mutations
All 767 amino-acid changes on canonical ENST00000269305 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TP53 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TP53 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 26/40 65% | 0/0 0% |
| Glioblastoma | 56/98 57% | 0/0 0% |
| Esophageal Squamous Cell Carcinoma | 35/51 69% | 1309/2550 51% |
| Ovarian Carcinoma | 49/109 45% | 488/998 49% |
| Squamous Cell Lung Carcinoma | 28/57 49% | 379/810 47% |
| Esophageal Carcinoma | 17/23 74% | 341/769 44% |
| T-Cell Non-Hodgkins Lymphoma | 11/26 42% | 0/0 0% |
| Colorectal Carcinoma | 72/143 50% | 1343/3239 41% |
| Oral Cavity Carcinoma | 22/54 41% | 0/0 0% |
| Small Cell Lung Carcinoma | 7/9 78% | 294/752 39% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 51/133 38% |
| Other Solid Cancers | 39/94 41% | 519/1515 34% |
| Non-Small Cell Lung Carcinoma | 177/304 58% | 409/1390 29% |
| Acute Myeloid Leukemia | 31/90 34% | 0/0 0% |
| Gastric Carcinoma | 44/74 59% | 600/1809 33% |
| Pancreatic Carcinoma | 55/89 62% | 526/1611 33% |
| Bladder Carcinoma | 37/58 64% | 293/956 31% |
| Glioma | 31/52 60% | 669/2127 31% |
| Chronic Myelogenous Leukemia | 8/25 32% | 0/0 0% |
| Neuroendocrine Tumour | 86/154 56% | 145/577 25% |
| Endometrial Carcinoma | 23/42 55% | 176/612 29% |
| Head and Neck Carcinoma | 42/85 49% | 461/1574 29% |
| Biliary Tract Carcinoma | 26/54 48% | 221/950 23% |
| Burkitts Lymphoma | 32/32 100% | 22/196 11% |
| Breast Carcinoma | 64/144 44% | 741/3264 23% |
| Hepatocellular Carcinoma | 22/46 48% | 510/2210 23% |
| Other Sarcomas | 20/69 29% | 160/699 23% |
| Acute Monocytic Leukemia | 1/1 100% | 5/25 20% |
| Osteosarcoma | 7/45 16% | 30/166 18% |
| Ewings Sarcoma | 35/63 56% | 19/262 7% |
Mutation Distribution
Where TP53 is mutated · all tissues, split by cell line vs tissue
How many mutations in TP53 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 196,883 mutations in TP53
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|