Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 769 | 281 | 485 |
| Samples | 611 | 242 | 366 |
| Peptides | 288 | 48 | 254 |
Function
MUC21 · Mucin 21, cell surface associated
This gene encodes a large membrane-bound glycoprotein which is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. The encoded protein contains an N-terminal signal sequence, an extracellular mucin domain, a stem domain, a transmembrane domain, and a C-terminal cytoplasmic tail domain. The mucin domain contains O-glycosylation sites and is polymorphic with isoforms containing a variable number of nonidentical proline-, threonine-, and serine-rich tandem repeats of 15 amino acids each. The aberrent expression of this gene is associated with lung adenocarcinoma. [provided by RefSeq, May 2017].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000376296 | Q5SSG8 | 734 | 284 |
| ENST00000486149 | A0A0C4DGM6* | 35 | 31 |
Gene Properties
Recurrent Mutations
All 286 amino-acid changes on canonical ENST00000376296 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in MUC21 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in MUC21 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Oral Cavity Carcinoma | 9/54 17% | 0/0 0% |
| Chronic Myelogenous Leukemia | 3/25 12% | 0/0 0% |
| Glioblastoma | 10/98 10% | 0/0 0% |
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Acute Myeloid Leukemia | 5/90 6% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Osteosarcoma | 6/45 13% | 1/166 1% |
| Neuroendocrine Tumour | 15/154 10% | 8/577 1% |
| Germ Cell Tumour | 3/25 12% | 3/169 2% |
| Melanoma | 14/210 7% | 50/1899 3% |
| Bladder Carcinoma | 6/58 10% | 23/956 2% |
| Non-Small Cell Lung Carcinoma | 21/304 7% | 20/1390 1% |
| Biliary Tract Carcinoma | 5/54 9% | 19/950 2% |
| Mesothelioma | 3/62 5% | 2/165 1% |
| Plasma Cell Myeloma | 2/44 5% | 4/305 1% |
| Endometrial Carcinoma | 3/42 7% | 8/612 1% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 11/810 1% |
| Meningioma | 0/3 0% | 4/252 2% |
| Ovarian Carcinoma | 9/109 8% | 7/998 1% |
| Colorectal Carcinoma | 15/143 10% | 33/3239 1% |
| Neuroblastoma | 9/87 10% | 11/1331 1% |
| Thyroid Gland Carcinoma | 4/45 9% | 17/1592 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 9/752 1% |
| Cervical Carcinoma | 2/35 6% | 3/422 1% |
| Other Solid Cancers | 2/94 2% | 15/1515 1% |
| Glioma | 15/52 29% | 7/2127 0% |
| Pancreatic Carcinoma | 8/89 9% | 7/1611 0% |
| Burkitts Lymphoma | 1/32 3% | 1/196 1% |
| Breast Carcinoma | 19/144 13% | 11/3264 0% |
| Adrenocortical Carcinoma | 1/3 33% | 0/112 0% |
Mutation Distribution
Where MUC21 is mutated · all tissues, split by cell line vs tissue
How many mutations in MUC21 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 769 mutations in MUC21
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|