Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 5,741 | 1,145 | 4,494 |
| Samples | 3,421 | 702 | 2,655 |
| Peptides | 3,050 | 579 | 2,595 |
Function
FAT3 · FAT atypical cadherin 3
Predicted to enable calcium ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within several processes, including negative regulation of dendrite development; neuron migration; and retina layer formation. Predicted to be located in dendrite and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 2500 amino-acid changes on canonical ENST00000409404 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in FAT3 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in FAT3 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 20/40 50% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 5/26 19% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 104/304 34% | 219/1390 16% |
| Melanoma | 44/210 21% | 340/1899 18% |
| Endometrial Carcinoma | 23/42 55% | 92/612 15% |
| Acute Myeloid Leukemia | 15/90 17% | 0/0 0% |
| Glioblastoma | 16/98 16% | 0/0 0% |
| Gastric Carcinoma | 18/74 24% | 262/1809 14% |
| Oral Cavity Carcinoma | 8/54 15% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 18/57 32% | 94/810 12% |
| Neuroendocrine Tumour | 56/154 36% | 26/577 5% |
| Colorectal Carcinoma | 50/143 35% | 328/3239 10% |
| Esophageal Carcinoma | 5/23 22% | 63/769 8% |
| Other Solid Cancers | 10/94 11% | 119/1515 8% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Hodgkins Lymphoma | 8/16 50% | 3/122 2% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 10/133 8% |
| Small Cell Lung Carcinoma | 5/9 56% | 49/752 7% |
| Plasma Cell Myeloma | 12/44 27% | 12/305 4% |
| Esophageal Squamous Cell Carcinoma | 16/51 31% | 159/2550 6% |
| Bladder Carcinoma | 8/58 14% | 59/956 6% |
| Ovarian Carcinoma | 26/109 24% | 42/998 4% |
| Head and Neck Carcinoma | 10/85 12% | 90/1574 6% |
| Cervical Carcinoma | 5/35 14% | 22/422 5% |
| Non-Cancerous | 13/104 12% | 40/830 5% |
| Germ Cell Tumour | 6/25 24% | 5/169 3% |
| Hepatocellular Carcinoma | 7/46 15% | 112/2210 5% |
| Chordoma | 1/7 14% | 0/13 0% |
| Biliary Tract Carcinoma | 5/54 9% | 45/950 5% |
| B-Cell Non-Hodgkins Lymphoma | 41/88 47% | 75/2534 3% |
Mutation Distribution
Where FAT3 is mutated · all tissues, split by cell line vs tissue
How many mutations in FAT3 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 5,741 mutations in FAT3
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|