Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 170 | 124 | 46 |
| Samples | 170 | 124 | 46 |
| Peptides | 23 | 12 | 13 |
Function
KRTAP9-6 · Keratin associated protein 9-6
Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000391355 | A8MVA2 | 170 | 23 |
Gene Properties
Recurrent Mutations
All 23 amino-acid changes on canonical ENST00000391355 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KRTAP9-6 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KRTAP9-6 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Mesothelioma | 4/62 6% | 0/165 0% |
| Non-Small Cell Lung Carcinoma | 22/304 7% | 0/1390 0% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Thyroid Gland Carcinoma | 3/45 7% | 13/1592 1% |
| Endometrial Carcinoma | 5/42 12% | 1/612 0% |
| Biliary Tract Carcinoma | 7/54 13% | 2/950 0% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Neuroendocrine Tumour | 4/154 3% | 0/577 0% |
| Ovarian Carcinoma | 6/109 6% | 0/998 0% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 10/2550 0% |
| Cervical Carcinoma | 1/35 3% | 1/422 0% |
| Wilms Tumour | 2/5 40% | 0/474 0% |
| Other Sarcomas | 3/69 4% | 0/699 0% |
| Meningioma | 1/3 33% | 0/252 0% |
| Head and Neck Carcinoma | 6/85 7% | 0/1574 0% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 0/810 0% |
| Melanoma | 7/210 3% | 0/1899 0% |
| Ewings Sarcoma | 1/63 2% | 0/262 0% |
| Pancreatic Carcinoma | 5/89 6% | 0/1611 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Glioma | 5/52 10% | 1/2127 0% |
| Gastric Carcinoma | 3/74 4% | 2/1809 0% |
| Other Solid Cancers | 4/94 4% | 0/1515 0% |
Mutation Distribution
Where KRTAP9-6 is mutated · all tissues, split by cell line vs tissue
How many mutations in KRTAP9-6 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 170 mutations in KRTAP9-6
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|