Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 668 | 86 | 574 |
| Samples | 230 | 48 | 178 |
| Peptides | 179 | 28 | 157 |
Function
ACTG2 · Actin gamma 2, smooth muscle
Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of this gene is formed by removal of two N-terminal peptides.[provided by RefSeq, Dec 2010].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 161 amino-acid changes on canonical ENST00000345517 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ACTG2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ACTG2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Melanoma | 3/210 1% | 38/1899 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 12/810 1% |
| Non-Small Cell Lung Carcinoma | 8/304 3% | 15/1390 1% |
| Endometrial Carcinoma | 3/42 7% | 5/612 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Other Solid Cancers | 0/94 0% | 15/1515 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Gastric Carcinoma | 0/74 0% | 15/1809 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Cervical Carcinoma | 0/35 0% | 3/422 1% |
| Head and Neck Carcinoma | 2/85 2% | 7/1574 0% |
| Other Sarcomas | 3/69 4% | 1/699 0% |
| Hepatocellular Carcinoma | 0/46 0% | 11/2210 0% |
| Mesothelioma | 0/62 0% | 1/165 1% |
| Colorectal Carcinoma | 2/143 1% | 12/3239 0% |
| Bladder Carcinoma | 2/58 3% | 2/956 0% |
| Thyroid Gland Carcinoma | 2/45 4% | 4/1592 0% |
| Breast Carcinoma | 6/144 4% | 6/3264 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 9/2550 0% |
| Ovarian Carcinoma | 3/109 3% | 0/998 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 2/752 0% |
| Kidney Carcinoma | 2/85 2% | 3/1862 0% |
| Medulloblastoma | 0/0 0% | 1/450 0% |
| Non-Cancerous | 1/104 1% | 1/830 0% |
| Biliary Tract Carcinoma | 0/54 0% | 2/950 0% |
| Pancreatic Carcinoma | 0/89 0% | 3/1611 0% |
| Glioma | 0/52 0% | 4/2127 0% |
Mutation Distribution
Where ACTG2 is mutated · all tissues, split by cell line vs tissue
How many mutations in ACTG2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 668 mutations in ACTG2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|