Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,787 | 243 | 1,537 |
| Samples | 380 | 74 | 304 |
| Peptides | 332 | 56 | 292 |
Function
ACTN1 · Actinin alpha 1
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
5 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 298 amino-acid changes on canonical ENST00000394419 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ACTN1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ACTN1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 8/40 20% | 0/0 0% |
| Hodgkins Lymphoma | 4/16 25% | 3/122 2% |
| Endometrial Carcinoma | 7/42 17% | 26/612 4% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Colorectal Carcinoma | 10/143 7% | 61/3239 2% |
| Melanoma | 7/210 3% | 30/1899 2% |
| Non-Small Cell Lung Carcinoma | 9/304 3% | 16/1390 1% |
| Mesothelioma | 0/62 0% | 3/165 2% |
| Other Solid Cancers | 3/94 3% | 17/1515 1% |
| Gastric Carcinoma | 0/74 0% | 23/1809 1% |
| Bladder Carcinoma | 2/58 3% | 9/956 1% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Osteosarcoma | 1/45 2% | 1/166 1% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 7/810 1% |
| Glioma | 0/52 0% | 18/2127 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Hepatocellular Carcinoma | 0/46 0% | 15/2210 1% |
| Head and Neck Carcinoma | 0/85 0% | 10/1574 1% |
| Neuroendocrine Tumour | 3/154 2% | 1/577 0% |
| Non-Cancerous | 0/104 0% | 5/830 1% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 12/2550 0% |
| Ovarian Carcinoma | 4/109 4% | 2/998 0% |
| Other Sarcomas | 2/69 3% | 2/699 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 7/1592 0% |
| B-Cell Non-Hodgkins Lymphoma | 5/88 6% | 6/2534 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 3/752 0% |
| Kidney Carcinoma | 0/85 0% | 7/1862 0% |
| Pancreatic Carcinoma | 0/89 0% | 5/1611 0% |
Mutation Distribution
Where ACTN1 is mutated · all tissues, split by cell line vs tissue
How many mutations in ACTN1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,787 mutations in ACTN1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|