Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 612 | 82 | 524 |
| Samples | 347 | 64 | 279 |
| Peptides | 279 | 41 | 241 |
Function
ADAM11 · ADAM metallopeptidase domain 11
This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 267 amino-acid changes on canonical ENST00000200557 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ADAM11 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ADAM11 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 3/25 12% | 0/0 0% |
| Acute Myeloid Leukemia | 3/90 3% | 0/0 0% |
| Endometrial Carcinoma | 7/42 17% | 11/612 2% |
| Melanoma | 3/210 1% | 41/1899 2% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 14/304 5% | 19/1390 1% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Germ Cell Tumour | 1/25 4% | 2/169 1% |
| Colorectal Carcinoma | 5/143 4% | 39/3239 1% |
| Neuroendocrine Tumour | 7/154 5% | 2/577 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 9/810 1% |
| Bladder Carcinoma | 0/58 0% | 9/956 1% |
| Thyroid Gland Carcinoma | 1/45 2% | 13/1592 1% |
| Kidney Carcinoma | 1/85 1% | 15/1862 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 6/752 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 18/2550 1% |
| Esophageal Carcinoma | 0/23 0% | 5/769 1% |
| Ewings Sarcoma | 1/63 2% | 1/262 0% |
| Head and Neck Carcinoma | 1/85 1% | 9/1574 1% |
| Plasma Cell Myeloma | 0/44 0% | 2/305 1% |
| Other Solid Cancers | 0/94 0% | 9/1515 1% |
| Gastric Carcinoma | 0/74 0% | 10/1809 1% |
| Biliary Tract Carcinoma | 0/54 0% | 5/950 1% |
| Rhabdomyosarcoma | 0/33 0% | 1/171 1% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Glioma | 0/52 0% | 10/2127 0% |
| Ovarian Carcinoma | 1/109 1% | 4/998 0% |
| Cervical Carcinoma | 2/35 6% | 0/422 0% |
| Mesothelioma | 0/62 0% | 1/165 1% |
| Non-Cancerous | 0/104 0% | 4/830 0% |
Mutation Distribution
Where ADAM11 is mutated · all tissues, split by cell line vs tissue
How many mutations in ADAM11 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 612 mutations in ADAM11
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|