Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 961 | 191 | 743 |
| Samples | 862 | 162 | 673 |
| Peptides | 617 | 122 | 517 |
Function
ADAMTS5 · ADAM metallopeptidase with thrombospondin type 1 motif 5
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000284987 | Q9UNA0 | 961 | 617 |
Gene Properties
Recurrent Mutations
All 617 amino-acid changes on canonical ENST00000284987 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ADAMTS5 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ADAMTS5 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 8/42 19% | 25/612 4% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Gastric Carcinoma | 9/74 12% | 82/1809 5% |
| Non-Small Cell Lung Carcinoma | 30/304 10% | 51/1390 4% |
| Colorectal Carcinoma | 29/143 20% | 118/3239 4% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Other Solid Cancers | 7/94 7% | 49/1515 3% |
| Melanoma | 17/210 8% | 51/1899 3% |
| Squamous Cell Lung Carcinoma | 4/57 7% | 23/810 3% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Hodgkins Lymphoma | 2/16 12% | 2/122 2% |
| Small Cell Lung Carcinoma | 0/9 0% | 19/752 3% |
| Biliary Tract Carcinoma | 0/54 0% | 23/950 2% |
| Neuroendocrine Tumour | 7/154 5% | 9/577 2% |
| Bladder Carcinoma | 2/58 3% | 20/956 2% |
| Esophageal Carcinoma | 0/23 0% | 17/769 2% |
| Ewings Sarcoma | 4/63 6% | 2/262 1% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Rhabdomyosarcoma | 0/33 0% | 3/171 2% |
| Head and Neck Carcinoma | 3/85 4% | 21/1574 1% |
| Burkitts Lymphoma | 1/32 3% | 2/196 1% |
| Cervical Carcinoma | 0/35 0% | 6/422 1% |
| Non-Cancerous | 1/104 1% | 10/830 1% |
| Ovarian Carcinoma | 3/109 3% | 10/998 1% |
| Plasma Cell Myeloma | 3/44 7% | 1/305 0% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 25/2550 1% |
| Hepatocellular Carcinoma | 0/46 0% | 20/2210 1% |
Mutation Distribution
Where ADAMTS5 is mutated · all tissues, split by cell line vs tissue
How many mutations in ADAMTS5 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 961 mutations in ADAMTS5
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|