Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 6,033 | 735 | 5,234 |
| Samples | 1,709 | 304 | 1,385 |
| Peptides | 1,555 | 208 | 1,375 |
Function
ADGRG4 · Adhesion G protein-coupled receptor G4
This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 1543 amino-acid changes on canonical ENST00000394143 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ADGRG4 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ADGRG4 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Melanoma | 42/210 20% | 275/1899 14% |
| Endometrial Carcinoma | 11/42 26% | 71/612 12% |
| Chronic Myelogenous Leukemia | 3/25 12% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 51/304 17% | 150/1390 11% |
| Glioblastoma | 9/98 9% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 9/57 16% | 68/810 8% |
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Small Cell Lung Carcinoma | 2/9 22% | 41/752 5% |
| Other Solid Cancers | 11/94 12% | 77/1515 5% |
| Hodgkins Lymphoma | 3/16 19% | 4/122 3% |
| Neuroendocrine Tumour | 28/154 18% | 9/577 2% |
| Gastric Carcinoma | 10/74 14% | 82/1809 5% |
| Colorectal Carcinoma | 34/143 24% | 128/3239 4% |
| Bladder Carcinoma | 4/58 7% | 43/956 4% |
| Cervical Carcinoma | 6/35 17% | 14/422 3% |
| Biliary Tract Carcinoma | 1/54 2% | 39/950 4% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Head and Neck Carcinoma | 2/85 2% | 43/1574 3% |
| Unknown | 0/10 0% | 1/29 3% |
| Breast Carcinoma | 11/144 8% | 74/3264 2% |
| Ovarian Carcinoma | 6/109 6% | 21/998 2% |
| Other Sarcomas | 6/69 9% | 12/699 2% |
| Hepatocellular Carcinoma | 2/46 4% | 43/2210 2% |
| Glioma | 4/52 8% | 36/2127 2% |
| Adrenocortical Carcinoma | 2/3 67% | 0/112 0% |
| Meningioma | 0/3 0% | 4/252 2% |
| Germ Cell Tumour | 0/25 0% | 3/169 2% |
| Plasma Cell Myeloma | 1/44 2% | 4/305 1% |
| Pancreatic Carcinoma | 1/89 1% | 23/1611 1% |
| Pheochromocytoma and Paraganglioma | 0/0 0% | 1/71 1% |
Mutation Distribution
Where ADGRG4 is mutated · all tissues, split by cell line vs tissue
How many mutations in ADGRG4 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 37 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 6,033 mutations in ADGRG4
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|