Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,880 | 165 | 1,709 |
| Samples | 311 | 46 | 264 |
| Peptides | 242 | 28 | 220 |
Function
AGTR1 · Angiotensin II receptor type 1
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2020].
Isoforms & Proteins
8 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 224 amino-acid changes on canonical ENST00000349243 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in AGTR1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in AGTR1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Acute Myeloid Leukemia | 4/90 4% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 19/810 2% |
| Endometrial Carcinoma | 6/42 14% | 9/612 1% |
| Melanoma | 4/210 2% | 38/1899 2% |
| Non-Small Cell Lung Carcinoma | 9/304 3% | 24/1390 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Other Solid Cancers | 0/94 0% | 27/1515 2% |
| Small Cell Lung Carcinoma | 0/9 0% | 9/752 1% |
| Colorectal Carcinoma | 9/143 6% | 27/3239 1% |
| Head and Neck Carcinoma | 0/85 0% | 17/1574 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 17/2550 1% |
| Cervical Carcinoma | 0/35 0% | 3/422 1% |
| Gastric Carcinoma | 0/74 0% | 12/1809 1% |
| Other Sarcomas | 0/69 0% | 4/699 1% |
| Esophageal Carcinoma | 0/23 0% | 4/769 1% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 11/2534 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Biliary Tract Carcinoma | 0/54 0% | 4/950 0% |
| Breast Carcinoma | 4/144 3% | 8/3264 0% |
| Glioma | 2/52 4% | 5/2127 0% |
| Hepatocellular Carcinoma | 0/46 0% | 6/2210 0% |
| B-Lymphoblastic Leukemia | 0/55 0% | 6/2640 0% |
| Bladder Carcinoma | 0/58 0% | 2/956 0% |
| Other Blood Cancers | 0/61 0% | 5/2725 0% |
| Kidney Carcinoma | 1/85 1% | 2/1862 0% |
| Prostate Carcinoma | 0/13 0% | 3/2105 0% |
| Non-Cancerous | 0/104 0% | 1/830 0% |
| Ovarian Carcinoma | 0/109 0% | 1/998 0% |
Mutation Distribution
Where AGTR1 is mutated · all tissues, split by cell line vs tissue
How many mutations in AGTR1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,880 mutations in AGTR1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|