Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 918 | 96 | 808 |
| Samples | 446 | 65 | 373 |
| Peptides | 330 | 44 | 290 |
Function
ALOX5 · Arachidonate 5-lipoxygenase
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 323 amino-acid changes on canonical ENST00000374391 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ALOX5 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ALOX5 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 6/40 15% | 0/0 0% |
| Endometrial Carcinoma | 7/42 17% | 23/612 4% |
| Melanoma | 1/210 0% | 66/1899 3% |
| Other Solid Cancers | 1/94 1% | 43/1515 3% |
| Non-Small Cell Lung Carcinoma | 9/304 3% | 29/1390 2% |
| Colorectal Carcinoma | 11/143 8% | 48/3239 1% |
| Esophageal Carcinoma | 0/23 0% | 11/769 1% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 11/810 1% |
| Gastric Carcinoma | 3/74 4% | 22/1809 1% |
| Cervical Carcinoma | 0/35 0% | 6/422 1% |
| Mesothelioma | 2/62 3% | 0/165 0% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 6/752 1% |
| Bladder Carcinoma | 2/58 3% | 6/956 1% |
| Other Sarcomas | 3/69 4% | 3/699 0% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Hepatocellular Carcinoma | 0/46 0% | 16/2210 1% |
| Medulloblastoma | 0/0 0% | 3/450 1% |
| Pancreatic Carcinoma | 3/89 3% | 8/1611 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 15/2550 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 10/1592 1% |
| Head and Neck Carcinoma | 1/85 1% | 9/1574 1% |
| Ovarian Carcinoma | 2/109 2% | 4/998 0% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Biliary Tract Carcinoma | 0/54 0% | 4/950 0% |
| Prostate Carcinoma | 2/13 15% | 6/2105 0% |
| Glioma | 0/52 0% | 8/2127 0% |
| Breast Carcinoma | 4/144 3% | 6/3264 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Neuroendocrine Tumour | 1/154 1% | 1/577 0% |
Mutation Distribution
Where ALOX5 is mutated · all tissues, split by cell line vs tissue
How many mutations in ALOX5 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 918 mutations in ALOX5
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|