Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 423 | 70 | 339 |
| Samples | 387 | 69 | 307 |
| Peptides | 219 | 42 | 186 |
Function
ALPG · Alkaline phosphatase, germ cell
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000295453 | P10696 | 423 | 219 |
Gene Properties
Recurrent Mutations
All 219 amino-acid changes on canonical ENST00000295453 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ALPG · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ALPG – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 6/40 15% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Melanoma | 6/210 3% | 45/1899 2% |
| Thyroid Gland Carcinoma | 1/45 2% | 35/1592 2% |
| Endometrial Carcinoma | 2/42 5% | 10/612 2% |
| Colorectal Carcinoma | 10/143 7% | 48/3239 1% |
| Non-Small Cell Lung Carcinoma | 11/304 4% | 12/1390 1% |
| Gastric Carcinoma | 1/74 1% | 19/1809 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Neuroendocrine Tumour | 4/154 3% | 3/577 1% |
| Ovarian Carcinoma | 8/109 7% | 2/998 0% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 6/752 1% |
| Esophageal Carcinoma | 0/23 0% | 6/769 1% |
| Hepatocellular Carcinoma | 0/46 0% | 17/2210 1% |
| Biliary Tract Carcinoma | 0/54 0% | 7/950 1% |
| Other Solid Cancers | 0/94 0% | 11/1515 1% |
| Head and Neck Carcinoma | 0/85 0% | 11/1574 1% |
| Glioma | 0/52 0% | 13/2127 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 5/810 1% |
| Non-Cancerous | 0/104 0% | 5/830 1% |
| Other Sarcomas | 1/69 1% | 3/699 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 11/2534 0% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Pancreatic Carcinoma | 3/89 3% | 4/1611 0% |
| Kidney Carcinoma | 2/85 2% | 5/1862 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 9/2550 0% |
| Other Blood Cancers | 3/61 5% | 6/2725 0% |
| Breast Carcinoma | 2/144 1% | 9/3264 0% |
Mutation Distribution
Where ALPG is mutated · all tissues, split by cell line vs tissue
How many mutations in ALPG were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 423 mutations in ALPG
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|