Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,140 | 189 | 866 |
| Samples | 317 | 85 | 228 |
| Peptides | 295 | 52 | 219 |
Function
ANAPC5 · Anaphase promoting complex subunit 5
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 270 amino-acid changes on canonical ENST00000261819 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ANAPC5 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ANAPC5 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 6/40 15% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 2/26 8% | 0/0 0% |
| Endometrial Carcinoma | 6/42 14% | 18/612 3% |
| Burkitts Lymphoma | 3/32 9% | 1/196 1% |
| Bladder Carcinoma | 3/58 5% | 13/956 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 2/133 2% |
| Melanoma | 5/210 2% | 23/1899 1% |
| Colorectal Carcinoma | 11/143 8% | 30/3239 1% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 8/810 1% |
| Cervical Carcinoma | 2/35 6% | 3/422 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Gastric Carcinoma | 2/74 3% | 16/1809 1% |
| Small Cell Lung Carcinoma | 2/9 22% | 5/752 1% |
| Non-Cancerous | 3/104 3% | 5/830 1% |
| Neuroendocrine Tumour | 2/154 1% | 4/577 1% |
| Non-Small Cell Lung Carcinoma | 3/304 1% | 8/1390 1% |
| Other Solid Cancers | 2/94 2% | 8/1515 1% |
| Prostate Carcinoma | 0/13 0% | 13/2105 1% |
| Breast Carcinoma | 6/144 4% | 13/3264 0% |
| Glioma | 1/52 2% | 11/2127 1% |
| Hepatocellular Carcinoma | 1/46 2% | 11/2210 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 12/2550 0% |
| Kidney Carcinoma | 5/85 6% | 4/1862 0% |
| Ovarian Carcinoma | 2/109 2% | 3/998 0% |
| Thyroid Gland Carcinoma | 2/45 4% | 5/1592 0% |
| Other Sarcomas | 1/69 1% | 2/699 0% |
| Head and Neck Carcinoma | 3/85 4% | 2/1574 0% |
| Biliary Tract Carcinoma | 2/54 4% | 1/950 0% |
| B-Cell Non-Hodgkins Lymphoma | 6/88 7% | 1/2534 0% |
| Esophageal Carcinoma | 0/23 0% | 2/769 0% |
Mutation Distribution
Where ANAPC5 is mutated · all tissues, split by cell line vs tissue
How many mutations in ANAPC5 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,140 mutations in ANAPC5
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|