Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,320 | 212 | 1,106 |
| Samples | 385 | 93 | 290 |
| Peptides | 323 | 55 | 276 |
Function
ARHGAP11A · Rho GTPase activating protein 11A
This gene encodes a member of the Rho GTPase activating protein family. In response to DNA damage, the encoded protein interacts with the p53 tumor suppressor protein and stimulates its tetramerization, which results in cell-cycle arrest and apoptosis. A chromosomal deletion that includes this gene is one cause of Prader-Willi syndrome, and an intronic variant of this gene may be associated with sleep duration in children. This gene is highly expressed in colon cancers and in a human basal-like breast cancer cell line. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019].
Isoforms & Proteins
6 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 309 amino-acid changes on canonical ENST00000361627 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ARHGAP11A · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ARHGAP11A – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 6/40 15% | 0/0 0% |
| Acute Myeloid Leukemia | 4/90 4% | 0/0 0% |
| Endometrial Carcinoma | 4/42 10% | 22/612 4% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 6/57 11% | 16/810 2% |
| Melanoma | 6/210 3% | 31/1899 2% |
| Cervical Carcinoma | 1/35 3% | 7/422 2% |
| Colorectal Carcinoma | 5/143 4% | 50/3239 2% |
| Non-Small Cell Lung Carcinoma | 6/304 2% | 19/1390 1% |
| Neuroendocrine Tumour | 5/154 3% | 5/577 1% |
| Bladder Carcinoma | 1/58 2% | 12/956 1% |
| Mesothelioma | 2/62 3% | 0/165 0% |
| Burkitts Lymphoma | 1/32 3% | 1/196 1% |
| Other Solid Cancers | 0/94 0% | 14/1515 1% |
| Gastric Carcinoma | 1/74 1% | 15/1809 1% |
| Other Sarcomas | 2/69 3% | 4/699 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Glioma | 3/52 6% | 13/2127 1% |
| Biliary Tract Carcinoma | 2/54 4% | 5/950 1% |
| Breast Carcinoma | 12/144 8% | 12/3264 0% |
| Non-Cancerous | 1/104 1% | 5/830 1% |
| Ewings Sarcoma | 1/63 2% | 1/262 0% |
| Head and Neck Carcinoma | 5/85 6% | 5/1574 0% |
| Hepatocellular Carcinoma | 3/46 7% | 10/2210 0% |
| Plasma Cell Myeloma | 0/44 0% | 2/305 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 4/752 1% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 9/2550 0% |
| Kidney Carcinoma | 1/85 1% | 7/1862 0% |
Mutation Distribution
Where ARHGAP11A is mutated · all tissues, split by cell line vs tissue
How many mutations in ARHGAP11A were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,320 mutations in ARHGAP11A
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|