Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,527 | 240 | 1,261 |
| Samples | 726 | 144 | 568 |
| Peptides | 603 | 97 | 504 |
Function
ARHGEF11 · Rho guanine nucleotide exchange factor 11
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 588 amino-acid changes on canonical ENST00000368194 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ARHGEF11 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ARHGEF11 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 8/42 19% | 25/612 4% |
| Chordoma | 1/7 14% | 0/13 0% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Acute Myeloid Leukemia | 4/90 4% | 0/0 0% |
| Melanoma | 6/210 3% | 81/1899 4% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Cervical Carcinoma | 5/35 14% | 13/422 3% |
| Acute Monocytic Leukemia | 0/1 0% | 1/25 4% |
| Squamous Cell Lung Carcinoma | 4/57 7% | 29/810 4% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Colorectal Carcinoma | 22/143 15% | 87/3239 3% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Non-Small Cell Lung Carcinoma | 10/304 3% | 35/1390 3% |
| Plasma Cell Myeloma | 3/44 7% | 6/305 2% |
| Other Solid Cancers | 0/94 0% | 40/1515 3% |
| Bladder Carcinoma | 8/58 14% | 16/956 2% |
| Chondrosarcoma | 2/14 14% | 0/75 0% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Gastric Carcinoma | 5/74 7% | 30/1809 2% |
| Mesothelioma | 2/62 3% | 2/165 1% |
| Burkitts Lymphoma | 4/32 12% | 0/196 0% |
| Adrenocortical Carcinoma | 0/3 0% | 2/112 2% |
| Neuroendocrine Tumour | 5/154 3% | 7/577 1% |
| Ovarian Carcinoma | 9/109 8% | 7/998 1% |
| Osteosarcoma | 2/45 4% | 1/166 1% |
| Hepatocellular Carcinoma | 2/46 4% | 27/2210 1% |
| Esophageal Squamous Cell Carcinoma | 6/51 12% | 27/2550 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 9/752 1% |
| Breast Carcinoma | 9/144 6% | 27/3264 1% |
| Rhabdomyosarcoma | 0/33 0% | 2/171 1% |
Mutation Distribution
Where ARHGEF11 is mutated · all tissues, split by cell line vs tissue
How many mutations in ARHGEF11 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,527 mutations in ARHGEF11
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|