Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 965 | 136 | 818 |
| Samples | 356 | 75 | 277 |
| Peptides | 286 | 57 | 241 |
Function
ASPSCR1 · ASPSCR1 tether for SLC2A4, UBX domain containing
The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2011].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 235 amino-acid changes on canonical ENST00000306729 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ASPSCR1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ASPSCR1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 4/40 10% | 0/0 0% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| Burkitts Lymphoma | 2/32 6% | 5/196 3% |
| Melanoma | 10/210 5% | 44/1899 2% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 3/133 2% |
| Endometrial Carcinoma | 2/42 5% | 12/612 2% |
| Plasma Cell Myeloma | 4/44 9% | 2/305 1% |
| Bladder Carcinoma | 1/58 2% | 14/956 1% |
| Mesothelioma | 1/62 2% | 2/165 1% |
| Other Solid Cancers | 0/94 0% | 20/1515 1% |
| Colorectal Carcinoma | 7/143 5% | 34/3239 1% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 8/810 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Cervical Carcinoma | 0/35 0% | 5/422 1% |
| Gastric Carcinoma | 0/74 0% | 20/1809 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Non-Cancerous | 1/104 1% | 8/830 1% |
| Non-Small Cell Lung Carcinoma | 4/304 1% | 12/1390 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 13/1592 1% |
| Small Cell Lung Carcinoma | 3/9 33% | 3/752 0% |
| Head and Neck Carcinoma | 0/85 0% | 12/1574 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Ovarian Carcinoma | 5/109 5% | 3/998 0% |
| Pancreatic Carcinoma | 4/89 4% | 7/1611 0% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Other Sarcomas | 1/69 1% | 3/699 0% |
| Glioma | 0/52 0% | 10/2127 0% |
| Breast Carcinoma | 6/144 4% | 9/3264 0% |
| Kidney Carcinoma | 4/85 5% | 4/1862 0% |
Mutation Distribution
Where ASPSCR1 is mutated · all tissues, split by cell line vs tissue
How many mutations in ASPSCR1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 965 mutations in ASPSCR1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|