Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 379 | 32 | 338 |
| Samples | 359 | 31 | 319 |
| Peptides | 274 | 27 | 251 |
Function
ATP5MF-PTCD1 · ATP5MF-PTCD1 readthrough
This locus represents naturally occurring read-through transcription between the ATP5J2 (ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2) and PTCD1 (pentatricopeptide repeat domain 1) genes on chromosome 7. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000413834 | G3V325* | 379 | 274 |
Gene Properties
Recurrent Mutations
All 274 amino-acid changes on canonical ENST00000413834 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ATP5MF-PTCD1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ATP5MF-PTCD1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Endometrial Carcinoma | 1/42 2% | 18/612 3% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Melanoma | 3/210 1% | 37/1899 2% |
| Other Solid Cancers | 1/94 1% | 29/1515 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Gastric Carcinoma | 0/74 0% | 34/1809 2% |
| Non-Small Cell Lung Carcinoma | 7/304 2% | 16/1390 1% |
| Colorectal Carcinoma | 5/143 4% | 41/3239 1% |
| Cervical Carcinoma | 0/35 0% | 6/422 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 11/810 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Bladder Carcinoma | 0/58 0% | 11/956 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 7/752 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 14/1592 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 19/2550 1% |
| Head and Neck Carcinoma | 2/85 2% | 9/1574 1% |
| Hepatocellular Carcinoma | 1/46 2% | 13/2210 1% |
| Ewings Sarcoma | 0/63 0% | 2/262 1% |
| Glioma | 1/52 2% | 12/2127 1% |
| Neuroendocrine Tumour | 1/154 1% | 3/577 1% |
| Osteosarcoma | 0/45 0% | 1/166 1% |
| Ovarian Carcinoma | 1/109 1% | 4/998 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Breast Carcinoma | 2/144 1% | 12/3264 0% |
| Other Sarcomas | 0/69 0% | 3/699 0% |
| Esophageal Carcinoma | 0/23 0% | 3/769 0% |
| Non-Cancerous | 0/104 0% | 3/830 0% |
| Biliary Tract Carcinoma | 0/54 0% | 3/950 0% |
| Medulloblastoma | 0/0 0% | 1/450 0% |
Mutation Distribution
Where ATP5MF-PTCD1 is mutated · all tissues, split by cell line vs tissue
How many mutations in ATP5MF-PTCD1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 379 mutations in ATP5MF-PTCD1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|