Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,837 | 162 | 1,665 |
| Samples | 237 | 36 | 198 |
| Peptides | 142 | 25 | 120 |
Function
AURKA · Aurora kinase A
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
8 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 136 amino-acid changes on canonical ENST00000395915 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in AURKA · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in AURKA – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Gastrointestinal Stromal Tumour | 0/0 0% | 39/133 29% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Endometrial Carcinoma | 5/42 12% | 8/612 1% |
| Melanoma | 7/210 3% | 18/1899 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Colorectal Carcinoma | 11/143 8% | 22/3239 1% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Neuroendocrine Tumour | 3/154 2% | 2/577 0% |
| Gastric Carcinoma | 0/74 0% | 12/1809 1% |
| Bladder Carcinoma | 0/58 0% | 6/956 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 15/2550 1% |
| Glioma | 0/52 0% | 12/2127 1% |
| Non-Cancerous | 0/104 0% | 5/830 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 4/752 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Esophageal Carcinoma | 0/23 0% | 4/769 1% |
| Biliary Tract Carcinoma | 3/54 6% | 2/950 0% |
| Other Solid Cancers | 0/94 0% | 8/1515 1% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 4/810 0% |
| Mesothelioma | 0/62 0% | 1/165 1% |
| Non-Small Cell Lung Carcinoma | 0/304 0% | 5/1390 0% |
| Breast Carcinoma | 1/144 1% | 9/3264 0% |
| Hepatocellular Carcinoma | 1/46 2% | 5/2210 0% |
| Prostate Carcinoma | 0/13 0% | 5/2105 0% |
| Medulloblastoma | 0/0 0% | 1/450 0% |
| Other Sarcomas | 0/69 0% | 1/699 0% |
| Pancreatic Carcinoma | 0/89 0% | 2/1611 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 2/1592 0% |
| Kidney Carcinoma | 1/85 1% | 1/1862 0% |
Mutation Distribution
Where AURKA is mutated · all tissues, split by cell line vs tissue
How many mutations in AURKA were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,837 mutations in AURKA
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|