Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,571 | 163 | 1,364 |
| Samples | 557 | 86 | 455 |
| Peptides | 387 | 62 | 337 |
Function
AXIN2 · Axin 2
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 380 amino-acid changes on canonical ENST00000307078 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in AXIN2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in AXIN2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Gastrointestinal Stromal Tumour | 0/0 0% | 34/133 26% |
| T-Lymphoblastic Leukemia | 4/40 10% | 0/0 0% |
| Acute Myeloid Leukemia | 6/90 7% | 0/0 0% |
| Endometrial Carcinoma | 6/42 14% | 27/612 4% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Thymic Epithelial Tumor | 0/0 0% | 1/39 3% |
| Colorectal Carcinoma | 14/143 10% | 68/3239 2% |
| Neuroendocrine Tumour | 5/154 3% | 12/577 2% |
| Bladder Carcinoma | 1/58 2% | 22/956 2% |
| Gastric Carcinoma | 3/74 4% | 35/1809 2% |
| Melanoma | 4/210 2% | 36/1899 2% |
| Cervical Carcinoma | 2/35 6% | 5/422 1% |
| Esophageal Carcinoma | 0/23 0% | 11/769 1% |
| Non-Small Cell Lung Carcinoma | 10/304 3% | 13/1390 1% |
| Mesothelioma | 0/62 0% | 3/165 2% |
| Small Cell Lung Carcinoma | 0/9 0% | 9/752 1% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 7/810 1% |
| Ovarian Carcinoma | 3/109 3% | 8/998 1% |
| Hepatocellular Carcinoma | 1/46 2% | 21/2210 1% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 22/2550 1% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Other Solid Cancers | 0/94 0% | 14/1515 1% |
| Thyroid Gland Carcinoma | 1/45 2% | 13/1592 1% |
| Meningioma | 0/3 0% | 2/252 1% |
| Glioma | 0/52 0% | 16/2127 1% |
| Head and Neck Carcinoma | 0/85 0% | 12/1574 1% |
| Pancreatic Carcinoma | 3/89 3% | 9/1611 1% |
| Biliary Tract Carcinoma | 0/54 0% | 7/950 1% |
| Other Sarcomas | 1/69 1% | 4/699 1% |
| Breast Carcinoma | 3/144 2% | 17/3264 1% |
Mutation Distribution
Where AXIN2 is mutated · all tissues, split by cell line vs tissue
How many mutations in AXIN2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,571 mutations in AXIN2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|