Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 3,133 | 352 | 2,750 |
| Samples | 438 | 78 | 353 |
| Peptides | 376 | 67 | 312 |
Function
BCAR1 · BCAR1 scaffold protein, Cas family member
The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017].
Isoforms & Proteins
10 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000162330 | P56945 | 437 | 321 |
| ENST00000393422 | P56945-7 | 401 | 303 |
| ENST00000418647 | P56945-6 | 400 | 302 |
| ENST00000393420 | P56945-3 | 396 | 298 |
| ENST00000420641 | P56945-2 | 393 | 296 |
| ENST00000538440 | P56945-8 | 390 | 293 |
| ENST00000542031 | P56945-5 | 390 | 293 |
| ENST00000535626 | P56945-4 | 314 | 242 |
| ENST00000546196 | F5H855* | 10 | 9 |
| ENST00000562556 | F5H855* | 2 | 1 |
Gene Properties
Recurrent Mutations
All 321 amino-acid changes on canonical ENST00000162330 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in BCAR1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in BCAR1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Endometrial Carcinoma | 3/42 7% | 21/612 3% |
| Acute Myeloid Leukemia | 3/90 3% | 0/0 0% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Thymic Epithelial Tumor | 0/0 0% | 1/39 3% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Colorectal Carcinoma | 9/143 6% | 57/3239 2% |
| Melanoma | 6/210 3% | 32/1899 2% |
| Gastric Carcinoma | 2/74 3% | 31/1809 2% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 14/810 2% |
| Non-Small Cell Lung Carcinoma | 8/304 3% | 17/1390 1% |
| Bladder Carcinoma | 1/58 2% | 12/956 1% |
| Non-Cancerous | 3/104 3% | 8/830 1% |
| Chondrosarcoma | 1/14 7% | 0/75 0% |
| Neuroendocrine Tumour | 3/154 2% | 5/577 1% |
| Other Solid Cancers | 0/94 0% | 17/1515 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 17/1592 1% |
| Rhabdomyosarcoma | 1/33 3% | 1/171 1% |
| Head and Neck Carcinoma | 4/85 5% | 11/1574 1% |
| Biliary Tract Carcinoma | 2/54 4% | 7/950 1% |
| Ovarian Carcinoma | 3/109 3% | 6/998 1% |
| Other Sarcomas | 4/69 6% | 2/699 0% |
| Cervical Carcinoma | 0/35 0% | 3/422 1% |
| Glioma | 3/52 6% | 10/2127 0% |
| Hepatocellular Carcinoma | 1/46 2% | 12/2210 1% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 13/2550 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Esophageal Carcinoma | 0/23 0% | 4/769 1% |
| Kidney Carcinoma | 1/85 1% | 9/1862 0% |
Mutation Distribution
Where BCAR1 is mutated · all tissues, split by cell line vs tissue
How many mutations in BCAR1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 3,133 mutations in BCAR1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|