Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,209 | 197 | 988 |
| Samples | 581 | 125 | 445 |
| Peptides | 475 | 104 | 383 |
Function
BCR · BCR activator of RhoGEF and GTPase
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 468 amino-acid changes on canonical ENST00000305877 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in BCR · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in BCR – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 6/40 15% | 0/0 0% |
| Endometrial Carcinoma | 10/42 24% | 22/612 4% |
| Burkitts Lymphoma | 1/32 3% | 10/196 5% |
| Glioblastoma | 4/98 4% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Melanoma | 10/210 5% | 62/1899 3% |
| Acute Myeloid Leukemia | 3/90 3% | 0/0 0% |
| Unknown | 1/10 10% | 0/29 0% |
| Colorectal Carcinoma | 11/143 8% | 61/3239 2% |
| Gastric Carcinoma | 1/74 1% | 36/1809 2% |
| Non-Small Cell Lung Carcinoma | 11/304 4% | 20/1390 1% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 14/810 2% |
| Esophageal Carcinoma | 2/23 9% | 11/769 1% |
| Cervical Carcinoma | 0/35 0% | 7/422 2% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 2/133 2% |
| Bladder Carcinoma | 5/58 9% | 10/956 1% |
| B-Cell Non-Hodgkins Lymphoma | 6/88 7% | 27/2534 1% |
| Other Solid Cancers | 5/94 5% | 15/1515 1% |
| Plasma Cell Myeloma | 1/44 2% | 3/305 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 18/1592 1% |
| Other Sarcomas | 2/69 3% | 6/699 1% |
| Rhabdomyosarcoma | 2/33 6% | 0/171 0% |
| Non-Cancerous | 1/104 1% | 8/830 1% |
| Ovarian Carcinoma | 5/109 5% | 5/998 0% |
| Esophageal Squamous Cell Carcinoma | 3/51 6% | 20/2550 1% |
| Neuroendocrine Tumour | 4/154 3% | 2/577 0% |
| Hepatocellular Carcinoma | 3/46 7% | 14/2210 1% |
| Glioma | 0/52 0% | 16/2127 1% |
| Pancreatic Carcinoma | 3/89 3% | 9/1611 1% |
Mutation Distribution
Where BCR is mutated · all tissues, split by cell line vs tissue
How many mutations in BCR were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,209 mutations in BCR
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|