Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,397 | 132 | 1,254 |
| Samples | 661 | 66 | 591 |
| Peptides | 540 | 65 | 480 |
Function
BIVM-ERCC5 · BIVM-ERCC5 readthrough
This locus represents naturally occurring read-through transcription between the neighboring BIVM (basic, immunoglobulin-like variable motif containing) and ERCC5 (excision repair cross-complementing rodent repair deficiency, complementation group 5) genes on chromosome 13. The read-through transcript encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Feb 2011].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000639435 | R4GMW8* | 751 | 537 |
| ENST00000639132 | A0A1W2PS85* | 646 | 453 |
Gene Properties
Recurrent Mutations
All 537 amino-acid changes on canonical ENST00000639435 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in BIVM-ERCC5 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in BIVM-ERCC5 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Gastrointestinal Stromal Tumour | 0/0 0% | 34/133 26% |
| Endometrial Carcinoma | 2/42 5% | 37/612 6% |
| Melanoma | 2/210 1% | 84/1899 4% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Cervical Carcinoma | 1/35 3% | 12/422 3% |
| Non-Small Cell Lung Carcinoma | 19/304 6% | 28/1390 2% |
| Colorectal Carcinoma | 8/143 6% | 80/3239 2% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 19/810 2% |
| Gastric Carcinoma | 2/74 3% | 41/1809 2% |
| Hodgkins Lymphoma | 3/16 19% | 0/122 0% |
| Other Solid Cancers | 3/94 3% | 31/1515 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Bladder Carcinoma | 0/58 0% | 17/956 2% |
| Neuroendocrine Tumour | 3/154 2% | 7/577 1% |
| Hepatocellular Carcinoma | 1/46 2% | 23/2210 1% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Head and Neck Carcinoma | 0/85 0% | 17/1574 1% |
| Esophageal Carcinoma | 0/23 0% | 8/769 1% |
| Biliary Tract Carcinoma | 0/54 0% | 10/950 1% |
| Ovarian Carcinoma | 3/109 3% | 8/998 1% |
| Rhabdomyosarcoma | 1/33 3% | 1/171 1% |
| Ewings Sarcoma | 2/63 3% | 1/262 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 7/752 1% |
| Breast Carcinoma | 1/144 1% | 27/3264 1% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 19/2550 1% |
| Kidney Carcinoma | 1/85 1% | 12/1862 1% |
| Other Sarcomas | 1/69 1% | 4/699 1% |
| Non-Cancerous | 0/104 0% | 6/830 1% |
| Glioma | 1/52 2% | 12/2127 1% |
Mutation Distribution
Where BIVM-ERCC5 is mutated · all tissues, split by cell line vs tissue
How many mutations in BIVM-ERCC5 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 1,397 mutations in BIVM-ERCC5
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|