Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 294 | 37 | 232 |
| Samples | 262 | 36 | 220 |
| Peptides | 231 | 33 | 187 |
Function
BUB1B-PAK6 · BUB1B-PAK6 readthrough
This gene represents readthrough transcription between the genes BUB1B (mitotic checkpoint serine/threonine-protein kinase BUB1 beta) and PAK6 (serine/threonine-protein kinase PAK 6). The protein encoded by the readthrough transcripts is the same as the product of the downstream gene (PAK6). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000441369 | Q9NQU5 | 294 | 231 |
Gene Properties
Recurrent Mutations
All 231 amino-acid changes on canonical ENST00000441369 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in BUB1B-PAK6 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in BUB1B-PAK6 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Endometrial Carcinoma | 1/42 2% | 12/612 2% |
| Melanoma | 2/210 1% | 33/1899 2% |
| Pheochromocytoma and Paraganglioma | 0/0 0% | 1/71 1% |
| Gastric Carcinoma | 1/74 1% | 24/1809 1% |
| Cervical Carcinoma | 0/35 0% | 6/422 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Colorectal Carcinoma | 3/143 2% | 26/3239 1% |
| Non-Small Cell Lung Carcinoma | 6/304 2% | 8/1390 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 6/810 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 5/752 1% |
| Glioma | 0/52 0% | 14/2127 1% |
| Biliary Tract Carcinoma | 0/54 0% | 6/950 1% |
| Bladder Carcinoma | 2/58 3% | 4/956 0% |
| Head and Neck Carcinoma | 1/85 1% | 8/1574 1% |
| Non-Cancerous | 0/104 0% | 5/830 1% |
| Hepatocellular Carcinoma | 0/46 0% | 12/2210 1% |
| Other Sarcomas | 1/69 1% | 3/699 0% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Rhabdomyosarcoma | 1/33 3% | 0/171 0% |
| Ovarian Carcinoma | 2/109 2% | 3/998 0% |
| Mesothelioma | 1/62 2% | 0/165 0% |
| Esophageal Carcinoma | 0/23 0% | 3/769 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 7/2550 0% |
| Other Solid Cancers | 1/94 1% | 4/1515 0% |
| Ewings Sarcoma | 1/63 2% | 0/262 0% |
| Pancreatic Carcinoma | 0/89 0% | 5/1611 0% |
Mutation Distribution
Where BUB1B-PAK6 is mutated · all tissues, split by cell line vs tissue
How many mutations in BUB1B-PAK6 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 294 mutations in BUB1B-PAK6
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|