Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 7,070 | 799 | 6,164 |
| Samples | 1,122 | 204 | 900 |
| Peptides | 954 | 159 | 833 |
Function
CACNA1D · Calcium voltage-gated channel subunit alpha1 D
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012].
Isoforms & Proteins
9 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000350061 | Q01668 | 1,371 | 885 |
| ENST00000288139 | Q01668-2 | 1,164 | 814 |
| ENST00000636570 | A0A1B0GUN6* | 1,148 | 801 |
| ENST00000422281 | Q01668-3 | 1,141 | 800 |
| ENST00000637424 | A0A1B0GTN0* | 1,140 | 793 |
| ENST00000636938 | A0A1B0GUB6* | 840 | 601 |
| ENST00000638120 | A0A1B0GTP8* | 251 | 167 |
| ENST00000645528 | A0A5F9Z6M3* | 14 | 11 |
| ENST00000636627 | A0A1B0GWE1* | 1 | 1 |
Gene Properties
Recurrent Mutations
All 885 amino-acid changes on canonical ENST00000350061 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in CACNA1D · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in CACNA1D – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 8/40 20% | 0/0 0% |
| Chronic Myelogenous Leukemia | 3/25 12% | 0/0 0% |
| Endometrial Carcinoma | 11/42 26% | 58/612 9% |
| Melanoma | 17/210 8% | 158/1899 8% |
| Glioblastoma | 6/98 6% | 0/0 0% |
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| Colorectal Carcinoma | 29/143 20% | 134/3239 4% |
| Other Solid Cancers | 2/94 2% | 70/1515 5% |
| Gastric Carcinoma | 9/74 12% | 75/1809 4% |
| Hodgkins Lymphoma | 4/16 25% | 2/122 2% |
| Acute Myeloid Leukemia | 3/90 3% | 0/0 0% |
| Other Sarcomas | 8/69 12% | 13/699 2% |
| Non-Small Cell Lung Carcinoma | 13/304 4% | 33/1390 2% |
| Bladder Carcinoma | 4/58 7% | 23/956 2% |
| Cervical Carcinoma | 1/35 3% | 10/422 2% |
| Ovarian Carcinoma | 13/109 12% | 12/998 1% |
| Chondrosarcoma | 1/14 7% | 1/75 1% |
| Head and Neck Carcinoma | 2/85 2% | 35/1574 2% |
| Germ Cell Tumour | 0/25 0% | 4/169 2% |
| Non-Cancerous | 1/104 1% | 16/830 2% |
| Neuroendocrine Tumour | 4/154 3% | 8/577 1% |
| Glioma | 2/52 4% | 32/2127 2% |
| Ewings Sarcoma | 2/63 3% | 3/262 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 13/810 2% |
| Plasma Cell Myeloma | 3/44 7% | 2/305 1% |
| Pheochromocytoma and Paraganglioma | 0/0 0% | 1/71 1% |
| Breast Carcinoma | 7/144 5% | 38/3264 1% |
| Esophageal Squamous Cell Carcinoma | 4/51 8% | 30/2550 1% |
| Hepatocellular Carcinoma | 5/46 11% | 23/2210 1% |
| Kidney Carcinoma | 5/85 6% | 19/1862 1% |
Mutation Distribution
Where CACNA1D is mutated · all tissues, split by cell line vs tissue
How many mutations in CACNA1D were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 7,070 mutations in CACNA1D
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|