Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 77 | 9 | 66 |
| Samples | 76 | 9 | 65 |
| Peptides | 42 | 7 | 37 |
Function
CCL22 · C-C motif chemokine ligand 22
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Sep 2014].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000219235 | O00626 | 77 | 42 |
Gene Properties
Recurrent Mutations
All 42 amino-acid changes on canonical ENST00000219235 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in CCL22 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in CCL22 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Acute Monocytic Leukemia | 0/1 0% | 1/25 4% |
| Germ Cell Tumour | 2/25 8% | 0/169 0% |
| Cervical Carcinoma | 2/35 6% | 2/422 0% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Melanoma | 2/210 1% | 13/1899 1% |
| Endometrial Carcinoma | 0/42 0% | 4/612 1% |
| Bladder Carcinoma | 0/58 0% | 5/956 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 3/752 0% |
| Non-Cancerous | 1/104 1% | 2/830 0% |
| Pancreatic Carcinoma | 0/89 0% | 5/1611 0% |
| Gastric Carcinoma | 0/74 0% | 5/1809 0% |
| Colorectal Carcinoma | 0/143 0% | 8/3239 0% |
| Other Solid Cancers | 0/94 0% | 3/1515 0% |
| Non-Small Cell Lung Carcinoma | 1/304 0% | 2/1390 0% |
| Hepatocellular Carcinoma | 0/46 0% | 4/2210 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 0/810 0% |
| Glioma | 0/52 0% | 2/2127 0% |
| Prostate Carcinoma | 0/13 0% | 1/2105 0% |
Mutation Distribution
Where CCL22 is mutated · all tissues, split by cell line vs tissue
How many mutations in CCL22 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 77 mutations in CCL22
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|