Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,602 | 224 | 1,376 |
| Samples | 186 | 39 | 146 |
| Peptides | 199 | 23 | 178 |
Function
CD46 · CD46 molecule
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010].
Isoforms & Proteins
10 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000367042 | P15529-11 | 177 | 135 |
| ENST00000322875 | P15529-2 | 170 | 138 |
| ENST00000354848 | P15529-3 | 164 | 133 |
| ENST00000358170 | P15529 | 162 | 133 |
| ENST00000480003 | P15529-6 | 161 | 130 |
| ENST00000357714 | P15529-4 | 160 | 129 |
| ENST00000360212 | P15529-7 | 157 | 126 |
| ENST00000322918 | P15529-9 | 153 | 123 |
| ENST00000367041 | P15529-12 | 152 | 124 |
| ENST00000367047 | P15529-16 | 146 | 118 |
Gene Properties
Recurrent Mutations
All 135 amino-acid changes on canonical ENST00000367042 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in CD46 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in CD46 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Endometrial Carcinoma | 5/42 12% | 11/612 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Melanoma | 1/210 0% | 19/1899 1% |
| Non-Small Cell Lung Carcinoma | 7/304 2% | 8/1390 1% |
| Colorectal Carcinoma | 13/143 9% | 16/3239 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Cervical Carcinoma | 0/35 0% | 3/422 1% |
| Gastric Carcinoma | 0/74 0% | 12/1809 1% |
| Bladder Carcinoma | 0/58 0% | 6/956 1% |
| Ovarian Carcinoma | 3/109 3% | 3/998 0% |
| Hepatocellular Carcinoma | 0/46 0% | 12/2210 1% |
| Esophageal Carcinoma | 0/23 0% | 4/769 1% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 2/810 0% |
| Other Solid Cancers | 0/94 0% | 7/1515 0% |
| Mesothelioma | 1/62 2% | 0/165 0% |
| Breast Carcinoma | 2/144 1% | 8/3264 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Glioma | 0/52 0% | 6/2127 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 2/752 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 4/1592 0% |
| Prostate Carcinoma | 0/13 0% | 5/2105 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 5/2550 0% |
| Head and Neck Carcinoma | 0/85 0% | 3/1574 0% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 3/2534 0% |
| Neuroendocrine Tumour | 0/154 0% | 1/577 0% |
| Non-Cancerous | 0/104 0% | 1/830 0% |
| Kidney Carcinoma | 0/85 0% | 2/1862 0% |
| Biliary Tract Carcinoma | 0/54 0% | 1/950 0% |
| Pancreatic Carcinoma | 1/89 1% | 0/1611 0% |
Mutation Distribution
Where CD46 is mutated · all tissues, split by cell line vs tissue
How many mutations in CD46 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,602 mutations in CD46
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|