Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 784 | 110 | 649 |
| Samples | 275 | 57 | 213 |
| Peptides | 233 | 39 | 194 |
Function
CDC45 · Cell division cycle 45
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000263201 | O75419 | 290 | 209 |
| ENST00000437685 | O75419-3 | 258 | 197 |
| ENST00000404724 | O75419-2 | 228 | 174 |
| ENST00000407835 | A0A5K1VW85* | 8 | 6 |
Gene Properties
Recurrent Mutations
All 209 amino-acid changes on canonical ENST00000263201 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in CDC45 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in CDC45 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 3/25 12% | 0/0 0% |
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Chordoma | 0/7 0% | 1/13 8% |
| Acute Monocytic Leukemia | 0/1 0% | 1/25 4% |
| Endometrial Carcinoma | 1/42 2% | 23/612 4% |
| Unknown | 0/10 0% | 1/29 3% |
| Bladder Carcinoma | 6/58 10% | 10/956 1% |
| Hodgkins Lymphoma | 0/16 0% | 2/122 2% |
| Melanoma | 5/210 2% | 25/1899 1% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 11/810 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Colorectal Carcinoma | 7/143 5% | 30/3239 1% |
| Cervical Carcinoma | 3/35 9% | 2/422 0% |
| Mesothelioma | 2/62 3% | 0/165 0% |
| Burkitts Lymphoma | 0/32 0% | 2/196 1% |
| Other Solid Cancers | 2/94 2% | 12/1515 1% |
| Non-Small Cell Lung Carcinoma | 7/304 2% | 6/1390 0% |
| Esophageal Carcinoma | 0/23 0% | 6/769 1% |
| Gastric Carcinoma | 2/74 3% | 12/1809 1% |
| Neuroendocrine Tumour | 2/154 1% | 3/577 1% |
| Medulloblastoma | 0/0 0% | 3/450 1% |
| Hepatocellular Carcinoma | 0/46 0% | 12/2210 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 13/2550 1% |
| Thyroid Gland Carcinoma | 2/45 4% | 4/1592 0% |
| Breast Carcinoma | 0/144 0% | 12/3264 0% |
| Prostate Carcinoma | 1/13 8% | 6/2105 0% |
| Glioma | 0/52 0% | 7/2127 0% |
| Biliary Tract Carcinoma | 1/54 2% | 2/950 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 2/752 0% |
Mutation Distribution
Where CDC45 is mutated · all tissues, split by cell line vs tissue
How many mutations in CDC45 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 784 mutations in CDC45
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|