Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 2,543 | 283 | 2,234 |
| Samples | 889 | 143 | 736 |
| Peptides | 607 | 94 | 536 |
Function
CDH7 · Cadherin 7
This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types. Mutations in this gene may be associated with bipolar disease in human patients. This gene is present in a gene cluster on chromosome 18. [provided by RefSeq, May 2016].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 594 amino-acid changes on canonical ENST00000397968 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in CDH7 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in CDH7 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 5/40 12% | 0/0 0% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Endometrial Carcinoma | 6/42 14% | 42/612 7% |
| Melanoma | 19/210 9% | 135/1899 7% |
| Non-Small Cell Lung Carcinoma | 25/304 8% | 71/1390 5% |
| Glioblastoma | 5/98 5% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Other Solid Cancers | 5/94 5% | 67/1515 4% |
| Squamous Cell Lung Carcinoma | 5/57 9% | 32/810 4% |
| Neuroendocrine Tumour | 19/154 12% | 4/577 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 20/752 3% |
| Gastric Carcinoma | 0/74 0% | 45/1809 2% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Other Sarcomas | 2/69 3% | 15/699 2% |
| Cervical Carcinoma | 0/35 0% | 9/422 2% |
| Esophageal Carcinoma | 0/23 0% | 15/769 2% |
| Bladder Carcinoma | 0/58 0% | 19/956 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Hepatocellular Carcinoma | 1/46 2% | 39/2210 2% |
| Esophageal Squamous Cell Carcinoma | 3/51 6% | 38/2550 1% |
| Head and Neck Carcinoma | 4/85 5% | 22/1574 1% |
| Colorectal Carcinoma | 10/143 7% | 42/3239 1% |
| Biliary Tract Carcinoma | 0/54 0% | 13/950 1% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Ovarian Carcinoma | 3/109 3% | 8/998 1% |
| Breast Carcinoma | 9/144 6% | 20/3264 1% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 18/2534 1% |
| Pancreatic Carcinoma | 1/89 1% | 10/1611 1% |
| Neuroblastoma | 4/87 5% | 4/1331 0% |
| Rhabdomyosarcoma | 0/33 0% | 1/171 1% |
Mutation Distribution
Where CDH7 is mutated · all tissues, split by cell line vs tissue
How many mutations in CDH7 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 40 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 2,543 mutations in CDH7
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|