Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 188 | 49 | 135 |
| Samples | 184 | 47 | 133 |
| Peptides | 135 | 29 | 110 |
Function
CDK9 · Cyclin dependent kinase 9
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000373264 | P50750 | 188 | 135 |
Gene Properties
Recurrent Mutations
All 135 amino-acid changes on canonical ENST00000373264 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in CDK9 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in CDK9 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 8/40 20% | 0/0 0% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Endometrial Carcinoma | 0/42 0% | 8/612 1% |
| Plasma Cell Myeloma | 0/44 0% | 4/305 1% |
| Melanoma | 2/210 1% | 19/1899 1% |
| Non-Small Cell Lung Carcinoma | 10/304 3% | 7/1390 0% |
| Bladder Carcinoma | 2/58 3% | 8/956 1% |
| Cervical Carcinoma | 1/35 3% | 3/422 1% |
| Burkitts Lymphoma | 1/32 3% | 1/196 1% |
| Colorectal Carcinoma | 5/143 4% | 24/3239 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Gastric Carcinoma | 0/74 0% | 11/1809 1% |
| Neuroendocrine Tumour | 2/154 1% | 2/577 0% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Medulloblastoma | 0/0 0% | 2/450 0% |
| Hepatocellular Carcinoma | 0/46 0% | 10/2210 0% |
| Other Solid Cancers | 0/94 0% | 6/1515 0% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 1/810 0% |
| Ewings Sarcoma | 0/63 0% | 1/262 0% |
| Ovarian Carcinoma | 2/109 2% | 1/998 0% |
| Other Sarcomas | 1/69 1% | 1/699 0% |
| Head and Neck Carcinoma | 1/85 1% | 3/1574 0% |
| Glioma | 0/52 0% | 5/2127 0% |
| Non-Cancerous | 0/104 0% | 2/830 0% |
| Pancreatic Carcinoma | 0/89 0% | 3/1611 0% |
| B-Cell Non-Hodgkins Lymphoma | 3/88 3% | 1/2534 0% |
| Prostate Carcinoma | 2/13 15% | 1/2105 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 1/752 0% |
| Breast Carcinoma | 1/144 1% | 3/3264 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 2/2550 0% |
Mutation Distribution
Where CDK9 is mutated · all tissues, split by cell line vs tissue
How many mutations in CDK9 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 188 mutations in CDK9
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|