Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 847 | 94 | 746 |
| Samples | 313 | 47 | 261 |
| Peptides | 265 | 32 | 234 |
Function
CENPI · Centromere protein I
This gene encodes a centromere protein that is a component of the CENPA-NAC (nucleosome-associated) complex. This complex is critical for accurate chromosome alignment and segregation and it ensures proper mitotic progression. This protein regulates the recruitment of kinetochore-associated proteins that are required to generate the spindle checkpoint signal. The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. Mutations in this gene may be involved in human X-linked disorders of gonadal development and gametogenesis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 13. [provided by RefSeq, Jan 2016].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000372927 | Q92674 | 318 | 246 |
| ENST00000423383 | A0A8C8KX99* | 294 | 227 |
| ENST00000372926 | Q92674-2 | 209 | 163 |
| ENST00000682095 | Q92674 | 26 | 25 |
Gene Properties
Recurrent Mutations
All 246 amino-acid changes on canonical ENST00000372927 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in CENPI · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in CENPI – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Endometrial Carcinoma | 3/42 7% | 31/612 5% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Thyroid Gland Carcinoma | 1/45 2% | 22/1592 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 10/752 1% |
| Non-Small Cell Lung Carcinoma | 5/304 2% | 16/1390 1% |
| Melanoma | 2/210 1% | 24/1899 1% |
| Osteosarcoma | 2/45 4% | 0/166 0% |
| Bladder Carcinoma | 1/58 2% | 8/956 1% |
| Colorectal Carcinoma | 5/143 4% | 25/3239 1% |
| Neuroendocrine Tumour | 4/154 3% | 2/577 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 7/810 1% |
| Other Solid Cancers | 4/94 4% | 9/1515 1% |
| Hepatocellular Carcinoma | 2/46 4% | 15/2210 1% |
| Cervical Carcinoma | 0/35 0% | 3/422 1% |
| Other Sarcomas | 2/69 3% | 3/699 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 17/2550 1% |
| Gastric Carcinoma | 1/74 1% | 9/1809 0% |
| Biliary Tract Carcinoma | 0/54 0% | 5/950 1% |
| Ovarian Carcinoma | 0/109 0% | 5/998 0% |
| Burkitts Lymphoma | 0/32 0% | 1/196 1% |
| Meningioma | 0/3 0% | 1/252 0% |
| Breast Carcinoma | 4/144 3% | 9/3264 0% |
| Glioma | 0/52 0% | 8/2127 0% |
| Head and Neck Carcinoma | 1/85 1% | 5/1574 0% |
| Non-Cancerous | 0/104 0% | 3/830 0% |
| Kidney Carcinoma | 0/85 0% | 6/1862 0% |
| Other Blood Cancers | 1/61 2% | 7/2725 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Neuroblastoma | 1/87 1% | 3/1331 0% |
Mutation Distribution
Where CENPI is mutated · all tissues, split by cell line vs tissue
How many mutations in CENPI were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 847 mutations in CENPI
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|