Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,330 | 303 | 1,014 |
| Samples | 1,118 | 268 | 838 |
| Peptides | 986 | 172 | 829 |
Function
CEP350 · Centrosomal protein 350
The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 984 amino-acid changes on canonical ENST00000367607 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in CEP350 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in CEP350 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 9/40 22% | 0/0 0% |
| Endometrial Carcinoma | 13/42 31% | 56/612 9% |
| Acute Myeloid Leukemia | 9/90 10% | 0/0 0% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 2/26 8% | 0/0 0% |
| Melanoma | 18/210 9% | 122/1899 6% |
| Non-Small Cell Lung Carcinoma | 40/304 13% | 53/1390 4% |
| Unknown | 1/10 10% | 1/29 3% |
| Glioblastoma | 5/98 5% | 0/0 0% |
| Bladder Carcinoma | 2/58 3% | 42/956 4% |
| Cervical Carcinoma | 2/35 6% | 16/422 4% |
| Acute Monocytic Leukemia | 0/1 0% | 1/25 4% |
| Other Solid Cancers | 5/94 5% | 56/1515 4% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 5/133 4% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Colorectal Carcinoma | 39/143 27% | 84/3239 3% |
| Squamous Cell Lung Carcinoma | 7/57 12% | 23/810 3% |
| Neuroendocrine Tumour | 19/154 12% | 3/577 1% |
| Hodgkins Lymphoma | 0/16 0% | 4/122 3% |
| Burkitts Lymphoma | 5/32 16% | 1/196 1% |
| Gastric Carcinoma | 3/74 4% | 43/1809 2% |
| Head and Neck Carcinoma | 2/85 2% | 37/1574 2% |
| Ovarian Carcinoma | 8/109 7% | 15/998 2% |
| Germ Cell Tumour | 1/25 4% | 3/169 2% |
| Biliary Tract Carcinoma | 4/54 7% | 16/950 2% |
| Thyroid Gland Carcinoma | 5/45 11% | 26/1592 2% |
| Small Cell Lung Carcinoma | 0/9 0% | 14/752 2% |
| Breast Carcinoma | 12/144 8% | 45/3264 1% |
| Ewings Sarcoma | 3/63 5% | 2/262 1% |
| Non-Cancerous | 3/104 3% | 11/830 1% |
Mutation Distribution
Where CEP350 is mutated · all tissues, split by cell line vs tissue
How many mutations in CEP350 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,330 mutations in CEP350
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|