Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 685 | 98 | 571 |
| Samples | 289 | 50 | 231 |
| Peptides | 241 | 34 | 202 |
Function
CES3 · Carboxylesterase 3
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000303334 | Q6UWW8 | 306 | 226 |
| ENST00000394037 | A0A0C4DFY7* | 272 | 210 |
| ENST00000543856 | Q6UWW8-2 | 107 | 82 |
Gene Properties
Recurrent Mutations
All 226 amino-acid changes on canonical ENST00000303334 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in CES3 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in CES3 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Acute Myeloid Leukemia | 4/90 4% | 0/0 0% |
| Melanoma | 3/210 1% | 52/1899 3% |
| Endometrial Carcinoma | 0/42 0% | 16/612 3% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Colorectal Carcinoma | 10/143 7% | 39/3239 1% |
| Osteosarcoma | 2/45 4% | 1/166 1% |
| Bladder Carcinoma | 0/58 0% | 8/956 1% |
| Gastric Carcinoma | 1/74 1% | 13/1809 1% |
| Ovarian Carcinoma | 2/109 2% | 6/998 1% |
| Glioma | 1/52 2% | 14/2127 1% |
| Neuroendocrine Tumour | 3/154 2% | 2/577 0% |
| Non-Small Cell Lung Carcinoma | 3/304 1% | 8/1390 1% |
| Esophageal Carcinoma | 2/23 9% | 3/769 0% |
| Plasma Cell Myeloma | 0/44 0% | 2/305 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 12/2550 0% |
| Other Solid Cancers | 0/94 0% | 8/1515 1% |
| Cervical Carcinoma | 1/35 3% | 1/422 0% |
| Meningioma | 1/3 33% | 0/252 0% |
| Head and Neck Carcinoma | 1/85 1% | 5/1574 0% |
| Pancreatic Carcinoma | 0/89 0% | 6/1611 0% |
| Prostate Carcinoma | 2/13 15% | 5/2105 0% |
| Ewings Sarcoma | 0/63 0% | 1/262 0% |
| Biliary Tract Carcinoma | 0/54 0% | 3/950 0% |
| Hepatocellular Carcinoma | 0/46 0% | 6/2210 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 2/752 0% |
| Other Sarcomas | 0/69 0% | 2/699 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 2/810 0% |
Mutation Distribution
Where CES3 is mutated · all tissues, split by cell line vs tissue
How many mutations in CES3 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 685 mutations in CES3
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|