Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,959 | 263 | 1,646 |
| Samples | 650 | 123 | 514 |
| Peptides | 559 | 94 | 461 |
Function
CKAP5 · Cytoskeleton associated protein 5
This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 553 amino-acid changes on canonical ENST00000529230 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in CKAP5 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in CKAP5 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 4/25 16% | 0/0 0% |
| T-Lymphoblastic Leukemia | 6/40 15% | 0/0 0% |
| Endometrial Carcinoma | 14/42 33% | 34/612 6% |
| Glioblastoma | 4/98 4% | 0/0 0% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Burkitts Lymphoma | 2/32 6% | 5/196 3% |
| Melanoma | 8/210 4% | 56/1899 3% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 20/810 2% |
| Bladder Carcinoma | 0/58 0% | 26/956 3% |
| Thymic Epithelial Tumor | 0/0 0% | 1/39 3% |
| Colorectal Carcinoma | 15/143 10% | 66/3239 2% |
| Non-Small Cell Lung Carcinoma | 13/304 4% | 24/1390 2% |
| Gastric Carcinoma | 6/74 8% | 34/1809 2% |
| Adrenocortical Carcinoma | 0/3 0% | 2/112 2% |
| Other Solid Cancers | 0/94 0% | 28/1515 2% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 41/2550 2% |
| Cervical Carcinoma | 0/35 0% | 7/422 2% |
| Hodgkins Lymphoma | 2/16 12% | 0/122 0% |
| Neuroendocrine Tumour | 6/154 4% | 4/577 1% |
| Ovarian Carcinoma | 9/109 8% | 4/998 0% |
| Hepatocellular Carcinoma | 0/46 0% | 26/2210 1% |
| Head and Neck Carcinoma | 3/85 4% | 16/1574 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Other Sarcomas | 4/69 6% | 4/699 1% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Biliary Tract Carcinoma | 3/54 6% | 7/950 1% |
| Mesothelioma | 2/62 3% | 0/165 0% |
| Esophageal Carcinoma | 0/23 0% | 7/769 1% |
| Non-Cancerous | 1/104 1% | 7/830 1% |
| Breast Carcinoma | 4/144 3% | 24/3264 1% |
Mutation Distribution
Where CKAP5 is mutated · all tissues, split by cell line vs tissue
How many mutations in CKAP5 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,959 mutations in CKAP5
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|