Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,074 | 191 | 872 |
| Samples | 509 | 116 | 388 |
| Peptides | 409 | 81 | 332 |
Function
CLCA1 · Chloride channel accessory 1
This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 408 amino-acid changes on canonical ENST00000394711 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in CLCA1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in CLCA1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Hodgkins Lymphoma | 4/16 25% | 2/122 2% |
| Endometrial Carcinoma | 4/42 10% | 24/612 4% |
| Melanoma | 9/210 4% | 66/1899 3% |
| Non-Small Cell Lung Carcinoma | 12/304 4% | 26/1390 2% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 16/810 2% |
| Other Solid Cancers | 2/94 2% | 33/1515 2% |
| Germ Cell Tumour | 2/25 8% | 2/169 1% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Colorectal Carcinoma | 17/143 12% | 45/3239 1% |
| Neuroendocrine Tumour | 5/154 3% | 6/577 1% |
| Osteosarcoma | 3/45 7% | 0/166 0% |
| Pheochromocytoma and Paraganglioma | 0/0 0% | 1/71 1% |
| Bladder Carcinoma | 3/58 5% | 10/956 1% |
| Hepatocellular Carcinoma | 2/46 4% | 23/2210 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 8/752 1% |
| Ovarian Carcinoma | 4/109 4% | 6/998 1% |
| Head and Neck Carcinoma | 3/85 4% | 12/1574 1% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Plasma Cell Myeloma | 2/44 5% | 1/305 0% |
| Esophageal Squamous Cell Carcinoma | 4/51 8% | 18/2550 1% |
| Gastric Carcinoma | 3/74 4% | 11/1809 1% |
| Biliary Tract Carcinoma | 2/54 4% | 5/950 1% |
| Glioma | 0/52 0% | 15/2127 1% |
| Breast Carcinoma | 4/144 3% | 19/3264 1% |
| Pancreatic Carcinoma | 4/89 4% | 5/1611 0% |
| Other Sarcomas | 2/69 3% | 2/699 0% |
| Rhabdomyosarcoma | 1/33 3% | 0/171 0% |
Mutation Distribution
Where CLCA1 is mutated · all tissues, split by cell line vs tissue
How many mutations in CLCA1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 48 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,074 mutations in CLCA1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|