Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,953 | 271 | 1,650 |
| Samples | 1,027 | 177 | 831 |
| Peptides | 844 | 128 | 730 |
Function
COL5A2 · Collagen type V alpha 2 chain
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000374866 | P05997 | 1,160 | 826 |
| ENST00000618828 | A0A087WYX9* | 793 | 590 |
Gene Properties
Recurrent Mutations
All 826 amino-acid changes on canonical ENST00000374866 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in COL5A2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in COL5A2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Melanoma | 16/210 8% | 196/1899 10% |
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 23/304 8% | 83/1390 6% |
| Endometrial Carcinoma | 3/42 7% | 34/612 6% |
| Squamous Cell Lung Carcinoma | 15/57 26% | 31/810 4% |
| Acute Myeloid Leukemia | 4/90 4% | 0/0 0% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Other Solid Cancers | 7/94 7% | 45/1515 3% |
| Bladder Carcinoma | 1/58 2% | 30/956 3% |
| Colorectal Carcinoma | 18/143 13% | 84/3239 3% |
| Gastric Carcinoma | 7/74 9% | 45/1809 2% |
| Unknown | 0/10 0% | 1/29 3% |
| Chondrosarcoma | 1/14 7% | 1/75 1% |
| Other Sarcomas | 7/69 10% | 9/699 1% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 15/752 2% |
| Neuroendocrine Tumour | 9/154 6% | 5/577 1% |
| Mesothelioma | 3/62 5% | 1/165 1% |
| Cervical Carcinoma | 0/35 0% | 8/422 2% |
| Adrenocortical Carcinoma | 2/3 67% | 0/112 0% |
| Ovarian Carcinoma | 9/109 8% | 10/998 1% |
| Esophageal Carcinoma | 1/23 4% | 12/769 2% |
| Germ Cell Tumour | 0/25 0% | 3/169 2% |
| Head and Neck Carcinoma | 2/85 2% | 22/1574 1% |
| Esophageal Squamous Cell Carcinoma | 4/51 8% | 31/2550 1% |
| Biliary Tract Carcinoma | 2/54 4% | 10/950 1% |
| Plasma Cell Myeloma | 3/44 7% | 1/305 0% |
| Hepatocellular Carcinoma | 0/46 0% | 23/2210 1% |
| Osteosarcoma | 2/45 4% | 0/166 0% |
Mutation Distribution
Where COL5A2 is mutated · all tissues, split by cell line vs tissue
How many mutations in COL5A2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,953 mutations in COL5A2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|