Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 620 | 116 | 496 |
| Samples | 135 | 35 | 97 |
| Peptides | 99 | 30 | 67 |
Function
COMT · Catechol-O-methyltransferase
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008].
Isoforms & Proteins
6 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 83 amino-acid changes on canonical ENST00000361682 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in COMT · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in COMT – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 9/40 22% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 5/133 4% |
| Acute Myeloid Leukemia | 3/90 3% | 0/0 0% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Endometrial Carcinoma | 3/42 7% | 5/612 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Bladder Carcinoma | 0/58 0% | 9/956 1% |
| Burkitts Lymphoma | 0/32 0% | 2/196 1% |
| Colorectal Carcinoma | 5/143 4% | 15/3239 0% |
| Gastric Carcinoma | 1/74 1% | 9/1809 0% |
| Ovarian Carcinoma | 2/109 2% | 3/998 0% |
| Neuroendocrine Tumour | 2/154 1% | 1/577 0% |
| Thyroid Gland Carcinoma | 2/45 4% | 4/1592 0% |
| Hepatocellular Carcinoma | 0/46 0% | 8/2210 0% |
| Non-Small Cell Lung Carcinoma | 0/304 0% | 5/1390 0% |
| Melanoma | 1/210 0% | 5/1899 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 2/752 0% |
| Other Solid Cancers | 0/94 0% | 4/1515 0% |
| Head and Neck Carcinoma | 1/85 1% | 3/1574 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 2/810 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 4/2550 0% |
| Glioma | 1/52 2% | 2/2127 0% |
| Breast Carcinoma | 0/144 0% | 4/3264 0% |
| Pancreatic Carcinoma | 0/89 0% | 2/1611 0% |
| Prostate Carcinoma | 0/13 0% | 2/2105 0% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 1/2534 0% |
| Other Blood Cancers | 1/61 2% | 1/2725 0% |
| Neuroblastoma | 1/87 1% | 0/1331 0% |
| Kidney Carcinoma | 0/85 0% | 1/1862 0% |
| B-Lymphoblastic Leukemia | 0/55 0% | 1/2640 0% |
Mutation Distribution
Where COMT is mutated · all tissues, split by cell line vs tissue
How many mutations in COMT were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 620 mutations in COMT
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|