Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 487 | 51 | 434 |
| Samples | 448 | 50 | 396 |
| Peptides | 361 | 45 | 328 |
Function
CORO7-PAM16 · CORO7-PAM16 readthrough
This locus represents naturally occurring read-through transcription between the neighboring CORO7 (coronin 7) and PAM16 (presequence translocase-associated motor 16) genes on chromosome 16. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jan 2011].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 359 amino-acid changes on canonical ENST00000572467 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in CORO7-PAM16 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in CORO7-PAM16 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 3/25 12% | 0/0 0% |
| T-Lymphoblastic Leukemia | 4/40 10% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Endometrial Carcinoma | 1/42 2% | 27/612 4% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Melanoma | 4/210 2% | 43/1899 2% |
| Colorectal Carcinoma | 6/143 4% | 65/3239 2% |
| Other Solid Cancers | 1/94 1% | 30/1515 2% |
| Gastric Carcinoma | 1/74 1% | 34/1809 2% |
| Burkitts Lymphoma | 0/32 0% | 4/196 2% |
| Thyroid Gland Carcinoma | 0/45 0% | 25/1592 2% |
| Bladder Carcinoma | 1/58 2% | 14/956 1% |
| Hodgkins Lymphoma | 0/16 0% | 2/122 2% |
| Non-Small Cell Lung Carcinoma | 6/304 2% | 17/1390 1% |
| Ovarian Carcinoma | 5/109 5% | 8/998 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Cervical Carcinoma | 0/35 0% | 5/422 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 9/810 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Esophageal Carcinoma | 0/23 0% | 7/769 1% |
| Wilms Tumour | 0/5 0% | 4/474 1% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 19/2550 1% |
| Other Sarcomas | 2/69 3% | 4/699 1% |
| Biliary Tract Carcinoma | 0/54 0% | 7/950 1% |
| Neuroendocrine Tumour | 2/154 1% | 2/577 0% |
| Germ Cell Tumour | 1/25 4% | 0/169 0% |
| Breast Carcinoma | 3/144 2% | 14/3264 0% |
| Mesothelioma | 1/62 2% | 0/165 0% |
| Head and Neck Carcinoma | 0/85 0% | 7/1574 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 3/752 0% |
Mutation Distribution
Where CORO7-PAM16 is mutated · all tissues, split by cell line vs tissue
How many mutations in CORO7-PAM16 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 487 mutations in CORO7-PAM16
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|