Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 9,306 | 1,148 | 8,049 |
| Samples | 2,515 | 436 | 2,044 |
| Peptides | 2,225 | 365 | 1,951 |
Function
CSMD2 · CUB and Sushi multiple domains 2
The protein encoded by this gene is thought to be involved in the control of complement cascade of the immune system. Defects in this gene have been associated with schizophrenia. This gene may act as a tumor suppressor for colorectal cancer. [provided by RefSeq, Jan 2020].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000373381 | Q7Z408-4 | 3,362 | 2,091 |
| ENST00000373388 | Q7Z408 | 2,980 | 1,980 |
| ENST00000619121 | A0A087X0K4* | 2,964 | 1,958 |
Gene Properties
Recurrent Mutations
All 2091 amino-acid changes on canonical ENST00000373381 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in CSMD2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in CSMD2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 16/40 40% | 0/0 0% |
| Chronic Myelogenous Leukemia | 8/25 32% | 0/0 0% |
| Melanoma | 45/210 21% | 398/1899 21% |
| Oral Cavity Carcinoma | 10/54 19% | 0/0 0% |
| Endometrial Carcinoma | 15/42 36% | 75/612 12% |
| Non-Small Cell Lung Carcinoma | 67/304 22% | 142/1390 10% |
| Squamous Cell Lung Carcinoma | 12/57 21% | 85/810 10% |
| Chordoma | 2/7 29% | 0/13 0% |
| Colorectal Carcinoma | 49/143 34% | 253/3239 8% |
| Gastric Carcinoma | 11/74 15% | 144/1809 8% |
| T-Cell Non-Hodgkins Lymphoma | 2/26 8% | 0/0 0% |
| Small Cell Lung Carcinoma | 1/9 11% | 55/752 7% |
| Other Solid Cancers | 5/94 5% | 106/1515 7% |
| Acute Myeloid Leukemia | 6/90 7% | 0/0 0% |
| Neuroendocrine Tumour | 24/154 16% | 16/577 3% |
| Plasma Cell Myeloma | 8/44 18% | 11/305 4% |
| Cervical Carcinoma | 8/35 23% | 14/422 3% |
| Esophageal Carcinoma | 2/23 9% | 35/769 5% |
| Bladder Carcinoma | 1/58 2% | 46/956 5% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Ovarian Carcinoma | 19/109 17% | 30/998 3% |
| Esophageal Squamous Cell Carcinoma | 10/51 20% | 98/2550 4% |
| Head and Neck Carcinoma | 6/85 7% | 60/1574 4% |
| Hepatocellular Carcinoma | 6/46 13% | 81/2210 4% |
| Pancreatic Carcinoma | 11/89 12% | 47/1611 3% |
| Other Sarcomas | 6/69 9% | 20/699 3% |
| Thyroid Gland Carcinoma | 4/45 9% | 48/1592 3% |
| Non-Cancerous | 2/104 2% | 27/830 3% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Mesothelioma | 6/62 10% | 0/165 0% |
Mutation Distribution
Where CSMD2 is mutated · all tissues, split by cell line vs tissue
How many mutations in CSMD2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 9,306 mutations in CSMD2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|