CSNK2A1 Casein kinase 2 alpha 1 P68400 CSK21_HUMAN
Protein Coding Chr 20 20p13 Swiss-Prot reviewed Entrez 1457
Mutations
3,683
CL 286 · Tissue 3,305
Samples
232
CL 35 · Tissue 192
Peptides
212
unique mutant peptides
Transcripts
21
isoforms mutated

Stats by Source

Global, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)

How the counts split by source
Stats by Source

Global = all mutations for this gene across every source.

Cell line = COSMIC Cell Lines Project + DepMap + PubMed.

Tissue = COSMIC primary-tissue (patient tumour) samples.

Global can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.

GlobalCell lineTissue
Mutations3,6832863,305
Samples23235192
Peptides21222195

Function

CSNK2A1 · Casein kinase 2 alpha 1

Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. Multiple transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Apr 2018].

Isoforms & Proteins

21 transcripts · UniProt mapping is sequence-verified (AA-safe)

About the isoform mapping
Isoforms & Proteins

Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.

The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.

Counts are mutations and unique mutant peptides on each transcript.

TranscriptUniProtMutationsPeptides
ENST00000217244 P68400 230 149
ENST00000400217 P68400 210 146
ENST00000643660 P68400 210 146
ENST00000645623 P68400 210 146
ENST00000646305 P68400 210 146
ENST00000646561 P68400 210 146
ENST00000646814 P68400 210 146
ENST00000647348 P68400 210 146
ENST00000645234 A0A2R8YD58* 205 140
ENST00000400227 E7EU96* 201 137
ENST00000642689 A0A2R8YFU2* 198 136
ENST00000644710 A0A2R8YFU2* 198 136
ENST00000644885 A0A2R8YF43* 198 136
ENST00000645260 A0A2R8YDP2* 192 131
ENST00000647026 A0A2R8Y5A0* 187 127
ENST00000349736 P68400-2 143 100
ENST00000644003 P68400-2 143 100
ENST00000646477 P68400-2 143 100
ENST00000643600 A0A2R8Y4H0* 131 92
ENST00000642160 A0A2R8Y797* 22 19
ENST00000645187 A0A2R8Y7T1* 22 18

Gene Properties

Type
Protein Coding
Chromosome
20
Cytoband
20p13
Entrez ID
1457
Aliases
CK2A1CKIICka1Cka2OCNDS

Recurrent Mutations

Top recurrent amino-acid changes along the protein · needle height = number of mutations

What this lollipop shows
Recurrent Mutations

A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).

X-axis = amino-acid position in the protein.

Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.

The most recurrent changes are labelled; hover any needle for the change, position and counts.

Mutation Distribution

Where CSNK2A1 is mutated · all tissues, split by cell line vs tissue

Mutation counts by tissue
Mutation Distribution

How many mutations in CSNK2A1 were found in each tissue, across the whole database.

Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.

This shows the cancer-context where this gene is recurrently altered.

GTEx Expression

Median TPM across 54 healthy tissues

GTEx Portal ↗
About the expression data
GTEx Expression

Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.

Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.

Scroll or drag the mini-axis below the chart to browse all tissues.

Mutations

All 3,683 mutations in CSNK2A1

About the mutation list
Mutations

Every mutation record for this gene, across all samples and sources.

The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).

Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.

IDSampleTranscriptAA Change CDSTypeSourcePeptide