Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,504 | 200 | 1,291 |
| Samples | 425 | 93 | 328 |
| Peptides | 301 | 53 | 257 |
Function
CYP4F3 · Cytochrome P450 family 4 subfamily F member 3
This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2019].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 269 amino-acid changes on canonical ENST00000221307 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in CYP4F3 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in CYP4F3 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 5/40 12% | 0/0 0% |
| Melanoma | 7/210 3% | 79/1899 4% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Endometrial Carcinoma | 1/42 2% | 22/612 4% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Osteosarcoma | 4/45 9% | 1/166 1% |
| Non-Small Cell Lung Carcinoma | 14/304 5% | 20/1390 1% |
| Gastric Carcinoma | 3/74 4% | 27/1809 1% |
| Other Solid Cancers | 3/94 3% | 21/1515 1% |
| Hodgkins Lymphoma | 0/16 0% | 2/122 2% |
| Squamous Cell Lung Carcinoma | 4/57 7% | 7/810 1% |
| Colorectal Carcinoma | 13/143 9% | 29/3239 1% |
| Other Sarcomas | 4/69 6% | 4/699 1% |
| Neuroendocrine Tumour | 5/154 3% | 2/577 0% |
| Bladder Carcinoma | 0/58 0% | 9/956 1% |
| Ovarian Carcinoma | 4/109 4% | 5/998 0% |
| Biliary Tract Carcinoma | 0/54 0% | 7/950 1% |
| Cervical Carcinoma | 0/35 0% | 3/422 1% |
| Esophageal Squamous Cell Carcinoma | 3/51 6% | 14/2550 1% |
| Non-Cancerous | 1/104 1% | 5/830 1% |
| Glioma | 0/52 0% | 14/2127 1% |
| Plasma Cell Myeloma | 2/44 5% | 0/305 0% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Rhabdomyosarcoma | 0/33 0% | 1/171 1% |
| Head and Neck Carcinoma | 1/85 1% | 7/1574 0% |
| Breast Carcinoma | 2/144 1% | 11/3264 0% |
| Kidney Carcinoma | 2/85 2% | 5/1862 0% |
| Pancreatic Carcinoma | 3/89 3% | 3/1611 0% |
| Ewings Sarcoma | 0/63 0% | 1/262 0% |
Mutation Distribution
Where CYP4F3 is mutated · all tissues, split by cell line vs tissue
How many mutations in CYP4F3 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,504 mutations in CYP4F3
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|