Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 3,378 | 390 | 2,952 |
| Samples | 1,615 | 242 | 1,355 |
| Peptides | 1,295 | 191 | 1,141 |
Function
DCC · DCC netrin 1 receptor
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 1235 amino-acid changes on canonical ENST00000442544 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in DCC · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in DCC – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 8/40 20% | 0/0 0% |
| Melanoma | 20/210 10% | 323/1899 17% |
| Chronic Myelogenous Leukemia | 4/25 16% | 0/0 0% |
| Glioblastoma | 10/98 10% | 0/0 0% |
| Endometrial Carcinoma | 9/42 21% | 54/612 9% |
| Squamous Cell Lung Carcinoma | 13/57 23% | 59/810 7% |
| Neuroendocrine Tumour | 31/154 20% | 17/577 3% |
| Non-Small Cell Lung Carcinoma | 33/304 11% | 70/1390 5% |
| Other Solid Cancers | 5/94 5% | 91/1515 6% |
| Gastric Carcinoma | 2/74 3% | 97/1809 5% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 7/133 5% |
| Bladder Carcinoma | 7/58 12% | 40/956 4% |
| Hodgkins Lymphoma | 4/16 25% | 2/122 2% |
| Colorectal Carcinoma | 16/143 11% | 126/3239 4% |
| Small Cell Lung Carcinoma | 0/9 0% | 32/752 4% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Rhabdomyosarcoma | 3/33 9% | 4/171 2% |
| Esophageal Carcinoma | 3/23 13% | 24/769 3% |
| Hepatocellular Carcinoma | 5/46 11% | 64/2210 3% |
| Cervical Carcinoma | 4/35 11% | 10/422 2% |
| Head and Neck Carcinoma | 3/85 4% | 44/1574 3% |
| Biliary Tract Carcinoma | 4/54 7% | 21/950 2% |
| Other Sarcomas | 5/69 7% | 13/699 2% |
| Burkitts Lymphoma | 5/32 16% | 0/196 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 54/2550 2% |
| Germ Cell Tumour | 2/25 8% | 2/169 1% |
| Ovarian Carcinoma | 6/109 6% | 16/998 2% |
| Osteosarcoma | 1/45 2% | 3/166 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Mesothelioma | 4/62 6% | 0/165 0% |
Mutation Distribution
Where DCC is mutated · all tissues, split by cell line vs tissue
How many mutations in DCC were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 52 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 3,378 mutations in DCC
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|