Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 758 | 116 | 632 |
| Samples | 362 | 65 | 292 |
| Peptides | 277 | 48 | 234 |
Function
DMP1 · Dentin matrix acidic phosphoprotein 1
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 270 amino-acid changes on canonical ENST00000339673 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in DMP1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in DMP1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Melanoma | 6/210 3% | 62/1899 3% |
| Hodgkins Lymphoma | 4/16 25% | 0/122 0% |
| Endometrial Carcinoma | 3/42 7% | 12/612 2% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 3/133 2% |
| Non-Small Cell Lung Carcinoma | 10/304 3% | 26/1390 2% |
| Other Solid Cancers | 2/94 2% | 31/1515 2% |
| Small Cell Lung Carcinoma | 0/9 0% | 12/752 2% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 9/810 1% |
| Neuroendocrine Tumour | 7/154 5% | 3/577 1% |
| Mesothelioma | 2/62 3% | 1/165 1% |
| Non-Cancerous | 2/104 2% | 9/830 1% |
| Colorectal Carcinoma | 5/143 4% | 32/3239 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Gastric Carcinoma | 2/74 3% | 17/1809 1% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Pancreatic Carcinoma | 2/89 2% | 10/1611 1% |
| Other Sarcomas | 2/69 3% | 3/699 0% |
| Plasma Cell Myeloma | 2/44 5% | 0/305 0% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Medulloblastoma | 0/0 0% | 2/450 0% |
| Biliary Tract Carcinoma | 0/54 0% | 4/950 0% |
| Hepatocellular Carcinoma | 1/46 2% | 8/2210 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 8/2534 0% |
| Head and Neck Carcinoma | 0/85 0% | 6/1574 0% |
| Ovarian Carcinoma | 0/109 0% | 4/998 0% |
| Glioma | 0/52 0% | 7/2127 0% |
| Bladder Carcinoma | 0/58 0% | 3/956 0% |
| Neuroblastoma | 0/87 0% | 4/1331 0% |
| Prostate Carcinoma | 0/13 0% | 4/2105 0% |
Mutation Distribution
Where DMP1 is mutated · all tissues, split by cell line vs tissue
How many mutations in DMP1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 26 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 758 mutations in DMP1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|