Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 3,422 | 438 | 2,964 |
| Samples | 926 | 166 | 753 |
| Peptides | 670 | 127 | 574 |
Function
DPP6 · Dipeptidyl peptidase like 6
This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
Isoforms & Proteins
6 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 523 amino-acid changes on canonical ENST00000377770 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in DPP6 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in DPP6 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 4/25 16% | 0/0 0% |
| Glioblastoma | 8/98 8% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 2/26 8% | 0/0 0% |
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Endometrial Carcinoma | 5/42 12% | 39/612 6% |
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 44/810 5% |
| Unknown | 0/10 0% | 2/29 7% |
| Non-Small Cell Lung Carcinoma | 15/304 5% | 65/1390 5% |
| Melanoma | 12/210 6% | 83/1899 4% |
| Small Cell Lung Carcinoma | 0/9 0% | 28/752 4% |
| Other Solid Cancers | 0/94 0% | 50/1515 3% |
| Colorectal Carcinoma | 17/143 12% | 85/3239 3% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Gastric Carcinoma | 3/74 4% | 47/1809 3% |
| Cervical Carcinoma | 2/35 6% | 10/422 2% |
| Rhabdomyosarcoma | 1/33 3% | 4/171 2% |
| Osteosarcoma | 4/45 9% | 1/166 1% |
| Neuroendocrine Tumour | 10/154 6% | 7/577 1% |
| Chondrosarcoma | 1/14 7% | 1/75 1% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Esophageal Squamous Cell Carcinoma | 5/51 10% | 47/2550 2% |
| Head and Neck Carcinoma | 1/85 1% | 29/1574 2% |
| Plasma Cell Myeloma | 5/44 11% | 1/305 0% |
| Hepatocellular Carcinoma | 4/46 9% | 34/2210 2% |
| Esophageal Carcinoma | 0/23 0% | 13/769 2% |
| Ovarian Carcinoma | 11/109 10% | 5/998 0% |
| Other Sarcomas | 2/69 3% | 9/699 1% |
| Pheochromocytoma and Paraganglioma | 0/0 0% | 1/71 1% |
| Breast Carcinoma | 16/144 11% | 28/3264 1% |
Mutation Distribution
Where DPP6 is mutated · all tissues, split by cell line vs tissue
How many mutations in DPP6 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 3,422 mutations in DPP6
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|