Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,296 | 183 | 1,100 |
| Samples | 385 | 87 | 293 |
| Peptides | 319 | 65 | 258 |
Function
DPP9 · Dipeptidyl peptidase 9
This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
5 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000262960 | Q86TI2-2 | 406 | 301 |
| ENST00000598800 | Q86TI2 | 340 | 265 |
| ENST00000594671 | Q86TI2-4 | 330 | 256 |
| ENST00000597849 | M0R2A8* | 215 | 168 |
| ENST00000646573 | A0A2R8YF65* | 5 | 5 |
Gene Properties
Recurrent Mutations
All 301 amino-acid changes on canonical ENST00000262960 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in DPP9 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in DPP9 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 5/40 12% | 0/0 0% |
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| Endometrial Carcinoma | 6/42 14% | 25/612 4% |
| Acute Myeloid Leukemia | 4/90 4% | 0/0 0% |
| Burkitts Lymphoma | 1/32 3% | 4/196 2% |
| Melanoma | 7/210 3% | 37/1899 2% |
| Colorectal Carcinoma | 13/143 9% | 52/3239 2% |
| Gastric Carcinoma | 2/74 3% | 28/1809 2% |
| Germ Cell Tumour | 1/25 4% | 2/169 1% |
| Thyroid Gland Carcinoma | 1/45 2% | 21/1592 1% |
| Plasma Cell Myeloma | 2/44 5% | 2/305 1% |
| Other Solid Cancers | 4/94 4% | 14/1515 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 4/304 1% | 13/1390 1% |
| Cervical Carcinoma | 1/35 3% | 3/422 1% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Hepatocellular Carcinoma | 2/46 4% | 15/2210 1% |
| Head and Neck Carcinoma | 3/85 4% | 9/1574 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Biliary Tract Carcinoma | 1/54 2% | 6/950 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 6/810 1% |
| Small Cell Lung Carcinoma | 2/9 22% | 3/752 0% |
| Other Sarcomas | 2/69 3% | 3/699 0% |
| Bladder Carcinoma | 0/58 0% | 6/956 1% |
| Neuroendocrine Tumour | 1/154 1% | 3/577 1% |
| Ovarian Carcinoma | 3/109 3% | 3/998 0% |
| Esophageal Carcinoma | 0/23 0% | 4/769 1% |
| Rhabdomyosarcoma | 0/33 0% | 1/171 1% |
| Esophageal Squamous Cell Carcinoma | 6/51 12% | 5/2550 0% |
| Ewings Sarcoma | 1/63 2% | 0/262 0% |
Mutation Distribution
Where DPP9 is mutated · all tissues, split by cell line vs tissue
How many mutations in DPP9 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,296 mutations in DPP9
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|