Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 913 | 132 | 762 |
| Samples | 474 | 101 | 365 |
| Peptides | 331 | 66 | 267 |
Function
ECEL1 · Endothelin converting enzyme like 1
This gene encodes a member of the M13 family of endopeptidases. Members of this family are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. Mutations in this gene are associated with autosomal recessive distal arthrogryposis, type 5D. This gene has multiple pseudogenes on chromosome 2. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 321 amino-acid changes on canonical ENST00000304546 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ECEL1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ECEL1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Glioblastoma | 5/98 5% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Endometrial Carcinoma | 7/42 17% | 11/612 2% |
| Melanoma | 8/210 4% | 43/1899 2% |
| Colorectal Carcinoma | 17/143 12% | 54/3239 2% |
| Gastric Carcinoma | 3/74 4% | 36/1809 2% |
| Non-Small Cell Lung Carcinoma | 15/304 5% | 17/1390 1% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 4/57 7% | 10/810 1% |
| Other Solid Cancers | 3/94 3% | 22/1515 1% |
| Hodgkins Lymphoma | 0/16 0% | 2/122 2% |
| Plasma Cell Myeloma | 2/44 5% | 3/305 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Neuroendocrine Tumour | 6/154 4% | 2/577 0% |
| Bladder Carcinoma | 0/58 0% | 10/956 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 16/1592 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 24/2550 1% |
| Mesothelioma | 2/62 3% | 0/165 0% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Glioma | 0/52 0% | 16/2127 1% |
| Biliary Tract Carcinoma | 1/54 2% | 6/950 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 5/752 1% |
| Prostate Carcinoma | 1/13 8% | 13/2105 1% |
| Non-Cancerous | 2/104 2% | 4/830 0% |
| Hepatocellular Carcinoma | 0/46 0% | 14/2210 1% |
| Ovarian Carcinoma | 5/109 5% | 1/998 0% |
| Other Sarcomas | 1/69 1% | 3/699 0% |
| Rhabdomyosarcoma | 1/33 3% | 0/171 0% |
Mutation Distribution
Where ECEL1 is mutated · all tissues, split by cell line vs tissue
How many mutations in ECEL1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 52 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 913 mutations in ECEL1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|