Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,264 | 95 | 1,151 |
| Samples | 318 | 24 | 286 |
| Peptides | 255 | 24 | 230 |
Function
EEF1A1 · Eukaryotic translation elongation factor 1 alpha 1
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
6 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000309268 | P68104 | 340 | 231 |
| ENST00000316292 | P68104 | 332 | 223 |
| ENST00000331523 | P68104 | 332 | 223 |
| ENST00000615060 | P68104 | 204 | 138 |
| ENST00000610520 | A0A087WVQ9* | 54 | 37 |
| ENST00000676547 | A0A7I2V3H3* | 2 | 2 |
Gene Properties
Recurrent Mutations
All 231 amino-acid changes on canonical ENST00000309268 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in EEF1A1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in EEF1A1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Hodgkins Lymphoma | 1/16 6% | 8/122 7% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Neuroendocrine Tumour | 1/154 1% | 13/577 2% |
| Endometrial Carcinoma | 1/42 2% | 10/612 2% |
| Melanoma | 3/210 1% | 28/1899 1% |
| Bladder Carcinoma | 0/58 0% | 14/956 1% |
| Non-Small Cell Lung Carcinoma | 10/304 3% | 13/1390 1% |
| Hepatocellular Carcinoma | 0/46 0% | 28/2210 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 18/1592 1% |
| Other Solid Cancers | 0/94 0% | 17/1515 1% |
| Esophageal Carcinoma | 0/23 0% | 7/769 1% |
| Glioma | 0/52 0% | 17/2127 1% |
| Head and Neck Carcinoma | 0/85 0% | 12/1574 1% |
| Biliary Tract Carcinoma | 0/54 0% | 7/950 1% |
| Colorectal Carcinoma | 3/143 2% | 20/3239 1% |
| Cervical Carcinoma | 1/35 3% | 2/422 0% |
| Breast Carcinoma | 0/144 0% | 18/3264 1% |
| Gastric Carcinoma | 0/74 0% | 10/1809 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 4/752 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Mesothelioma | 1/62 2% | 0/165 0% |
| Wilms Tumour | 0/5 0% | 2/474 0% |
| B-Cell Non-Hodgkins Lymphoma | 0/88 0% | 11/2534 0% |
| Other Sarcomas | 0/69 0% | 3/699 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 3/810 0% |
| Prostate Carcinoma | 0/13 0% | 7/2105 0% |
| Non-Cancerous | 1/104 1% | 2/830 0% |
| Kidney Carcinoma | 0/85 0% | 6/1862 0% |
| Pancreatic Carcinoma | 0/89 0% | 4/1611 0% |
| Medulloblastoma | 0/0 0% | 1/450 0% |
Mutation Distribution
Where EEF1A1 is mutated · all tissues, split by cell line vs tissue
How many mutations in EEF1A1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,264 mutations in EEF1A1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|