Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 516 | 49 | 460 |
| Samples | 477 | 45 | 427 |
| Peptides | 374 | 41 | 338 |
Function
EEF1AKMT4-ECE2 · EEF1AKMT4-ECE2 readthrough
This gene represents naturally occurring readthrough transcription between adjacent genes eukaryotic translation elongation factor 1 alpha lysine methyltransferase 4 (GeneID: 110599564) and endothelin converting enzyme 2 (GeneID:9718). The readthrough transcript representing this gene encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2017].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000402825 | P0DPD8 | 516 | 374 |
Gene Properties
Recurrent Mutations
All 374 amino-acid changes on canonical ENST00000402825 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in EEF1AKMT4-ECE2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in EEF1AKMT4-ECE2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Endometrial Carcinoma | 1/42 2% | 27/612 4% |
| Melanoma | 0/210 0% | 59/1899 3% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 17/810 2% |
| Colorectal Carcinoma | 7/143 5% | 63/3239 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 6/304 2% | 25/1390 2% |
| Bladder Carcinoma | 0/58 0% | 18/956 2% |
| Mesothelioma | 1/62 2% | 3/165 2% |
| Cervical Carcinoma | 1/35 3% | 7/422 2% |
| Gastric Carcinoma | 2/74 3% | 29/1809 2% |
| Other Solid Cancers | 1/94 1% | 25/1515 2% |
| Neuroendocrine Tumour | 5/154 3% | 5/577 1% |
| Ovarian Carcinoma | 2/109 2% | 10/998 1% |
| Biliary Tract Carcinoma | 1/54 2% | 9/950 1% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 22/2550 1% |
| Plasma Cell Myeloma | 1/44 2% | 2/305 1% |
| Head and Neck Carcinoma | 0/85 0% | 13/1574 1% |
| Other Sarcomas | 0/69 0% | 6/699 1% |
| Thyroid Gland Carcinoma | 1/45 2% | 11/1592 1% |
| Hodgkins Lymphoma | 1/16 6% | 0/122 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 5/752 1% |
| Glioma | 0/52 0% | 12/2127 1% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 12/2534 0% |
| Medulloblastoma | 0/0 0% | 2/450 0% |
| Breast Carcinoma | 1/144 1% | 13/3264 0% |
| Prostate Carcinoma | 0/13 0% | 8/2105 0% |
| Non-Cancerous | 1/104 1% | 2/830 0% |
| Ewings Sarcoma | 1/63 2% | 0/262 0% |
Mutation Distribution
Where EEF1AKMT4-ECE2 is mutated · all tissues, split by cell line vs tissue
How many mutations in EEF1AKMT4-ECE2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 516 mutations in EEF1AKMT4-ECE2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|